{"doi":"10.1021/acsami.5c17309","title":"Self-Regulated Cobalt–Zinc–Ferrite Nanoprobe for Targeted Chemomagnetic Hyperthermia in Cancer Therapy","abstract":"High Resolution Image Download MS PowerPoint Slide Chemo-magnetic hyperthermia is a promising alternative anticancer treatment strategy employed to synergize the therapeutic efficacy of chemotherapy and magnetic hyperthermia. Despite its potential efficacy, most chemo-magnetic hyperthermia strategies are limited owing to limited in vivo thermal conversion ability and inadequate local therapeutic temperatures with nontargeted, uncontrolled release of anticancer agents. Herein, we developed a targeted formulation of anticancer drug-loaded nanoprobe for site-specific chemo-magnetic hyperthermia. The engineered nanoprobe comprising doxorubicin-loaded cobalt–zinc–ferrite nanoparticles, surface-modified with estrone-3-hemisuccinate (TMNPs), exhibits enhanced magnetic properties, including elevated saturation magnetization and the ability to a prolonged constant therapeutic temperature (42–46 °C) under an alternating magnetic field of 20 mT. Targeted delivery was achieved via specific interaction with estrogen receptors (ERs), which resulted in markedly higher apoptosis (∼97%) in ER-positive MCF-7 cells compared to ER-negative controls. In vivo evaluation using a xenograft murine model of breast cancer demonstrated the efficacy of TMNPs in orchestrating a multifaceted therapeutic response through the synergistic integration of chemotherapeutic and hyperthermic modalities. Immunofluorescence analysis of tumor tissues post-treatment revealed the localized induction of thermal stress and upregulation of Heat Shock Protein 70 (HSP-70), a biomarker linked to enhanced immune cell infiltration and activation within the tumor microenvironment. Overall, this study presents a methodical effort to explore the effectiveness of cobalt–zinc–ferrite nanoprobe for chemo-magnetic hyperthermia effects that can be used for efficient, patient-specific, targeted, controlled anticancer therapy through chemodynamic–magnetic–thermal synergistic therapy.","journal":"ACS Applied Materials & Interfaces","year":2025,"id":549214,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1443941,"name":"Khyati Parmar","orcid":null,"position":1,"is_corresponding":false},{"id":1443422,"name":"Sumanta Ghosh","orcid":"0000-0002-0022-0279","position":2,"is_corresponding":false},{"id":1443423,"name":"K. Srinivasa Rao","orcid":"0000-0003-2541-6339","position":3,"is_corresponding":false},{"id":920190,"name":"K. H. Rao","orcid":null,"position":4,"is_corresponding":false},{"id":1443424,"name":"Aditya A. Singh","orcid":"0000-0002-5026-9599","position":5,"is_corresponding":false},{"id":1442776,"name":"Pankaj Kumar","orcid":"0000-0002-2275-9144","position":6,"is_corresponding":false},{"id":185676,"name":"Hemant Kumar","orcid":"0000-0002-6434-0245","position":7,"is_corresponding":false},{"id":1443942,"name":"Hema L. Turubilli","orcid":null,"position":8,"is_corresponding":false},{"id":270381,"name":"Subhash C. Chauhan","orcid":"0000-0002-3347-5120","position":9,"is_corresponding":false},{"id":270382,"name":"Murali M. Yallapu","orcid":"0000-0002-0073-8828","position":10,"is_corresponding":false},{"id":1443425,"name":"Govinda Kapusetti","orcid":"0000-0003-4484-9156","position":11,"is_corresponding":false},{"id":1443940,"name":"Mounika Choppadandi","orcid":null,"position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T02:54:07.823422Z","pmid":"41348522","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}