{"doi":"10.1021/acsami.5b03668","title":"Highly Uniform Perfluoropropane-Loaded Cerasomal Microbubbles As a Novel Ultrasound Contrast Agent","abstract":null,"journal":"ACS Applied Materials & Interfaces","year":2016,"id":604048,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1101167,"name":"Zhu Wang","orcid":"0000-0003-2936-5479","position":1,"is_corresponding":false},{"id":1549718,"name":"Chunan Wang","orcid":null,"position":2,"is_corresponding":false},{"id":1549719,"name":"Xiongjun Li","orcid":null,"position":3,"is_corresponding":false},{"id":831265,"name":"Jie Liu","orcid":"0000-0002-2373-7190","position":4,"is_corresponding":false},{"id":312183,"name":"Ming Xu","orcid":"0000-0001-7974-0658","position":5,"is_corresponding":false},{"id":312657,"name":"Shuyu Xu","orcid":"0000-0001-8568-0268","position":6,"is_corresponding":false},{"id":1549721,"name":"Xiaoyan Xie","orcid":null,"position":7,"is_corresponding":false},{"id":34095,"name":"Qing Jiang","orcid":null,"position":8,"is_corresponding":false},{"id":542963,"name":"Wei Wang","orcid":"0000-0001-8676-1190","position":9,"is_corresponding":false},{"id":1199221,"name":"Zhong Cao","orcid":"0000-0002-2243-5705","position":10,"is_corresponding":false},{"id":578582,"name":"Chunyang Zhang","orcid":"0000-0001-6794-5760","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Highly Uniform Perfluoropropane-Loaded Cerasomal Microbubbles As a Novel Ultrasound Contrast Agent","abstract":"Microbubbles are widely used as ultrasound contrast agents owing to their excellent echoing characteristics under ultrasound radiation. However, their short sonographic duration and wide size distribution still hinder their application. Herein, we present a hard-template approach to produce perfluoropropane-loaded cerasomal microbubbles (PLCMs) with uniform size and long sonographic duration. The preparation of PLCMs includes deposition of Si-lipids onto functionalized CaCO3 microspheres, removal of their CaCO3 cores and mild infusion of perfluoropropane. In vitro and in vivo experiments showed that PLCMs had excellent echoing characteristics under different ultrasound conditions. More importantly, PLCMs could be imaged for much longer than SonoVue (commercially used microbubbles) under the same ultrasound parameters and concentrations. Our results demonstrated that PLCMs have great potential for use as a novel contrast agent in ultrasound imaging.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26114237","pmcid":null,"openalex_id":"https://openalex.org/W2421589566","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81101142","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81301238","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"U1401242","title":null},{"funder_name":"Natural Science Foundation of Guangdong Province","grant_id":"2014A030312018","title":null},{"funder_name":"Guangdong Innovative Research Team Program","grant_id":"2009010057","title":null}],"total_grants":5,"fwci":1.3877,"citation_percentile":0.80288094,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":4},{"year":2018,"count":4},{"year":2019,"count":3},{"year":2020,"count":5},{"year":2021,"count":3},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acsami.5b03668","host_type":"publisher"},{"url":"https://doi.org/10.1021/acsami.5b03668","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26114237","host_type":"repository"}],"fields_of_study":["Ultrasound and Hyperthermia Applications","Photoacoustic and Ultrasonic Imaging","Ultrasound Imaging and Elastography","Contrast Media","Fluorocarbons","Microbubbles","Ultrasonography"],"mesh_terms":["Contrast Media","Fluorocarbons","Ultrasonography","Microbubbles"],"keywords":["Microbubbles","Ultrasound","Materials science","Contrast (vision)","Biomedical engineering","In vivo","Contrast-enhanced ultrasound","Ultrasound imaging","Microsphere","Radiology","Medicine","Chemical engineering","Optics","Stability","Ultrasound Contrast Agent","Si-lipid","Hard-template","Uniform Size Distribution"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T23:16:22.287091Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}