{"doi":"10.1021/acsami.4c00391","title":"Microphysiologically Engineered Vessel-Tumor Model to Investigate Vascular Transport Dynamics of Immune Cells","abstract":"Cancer immunotherapy has emerged as a promising therapeutic strategy to combat cancer effectively. However, it is hard to observe and quantify how this in vivo process happens. Three-dimensional (3D) microfluidic vessel-tumor models offer valuable capability to study how immune cells transport during cancer progression. We presented an advanced 3D vessel-supported tumor model consisting of the endothelial lumen and vessel network for the study of T cells' transportation. The process of T cell transport through the vessel network and interaction with tumor spheroids was represented and monitored in vitro. Specifically, we demonstrate that the endothelial glycocalyx serving in the T cells' transport can influence the endothelium-immune interaction. Furthermore, after vascular transport, how programmed cell death protein 1 (PD-1) immune checkpoint inhibition influences the delivered activated-T cells on tumor killing was evaluated. Our in vitro vessel-tumor model provides a microphysiologically engineered platform to represent T cell vascular transportation during tumor immunotherapy. The reported innovative vessel-tumor platform is believed to have the potential to explore the tumor-induced immune response mechanism and preclinically evaluate immunotherapy's effectiveness.","journal":"ACS Applied Materials & Interfaces","year":2024,"id":435154,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9433,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":699033,"name":"Yue Wu","orcid":"0000-0002-6564-2093","position":1,"is_corresponding":false},{"id":886960,"name":"Khayrul Islam","orcid":"0000-0003-2199-553X","position":2,"is_corresponding":false},{"id":401633,"name":"Ratul Paul","orcid":"0000-0003-0188-4365","position":3,"is_corresponding":false},{"id":302233,"name":"Yuyuan Zhou","orcid":"0000-0002-8317-4115","position":4,"is_corresponding":false},{"id":302234,"name":"Xiaochen Qin","orcid":"0000-0003-0051-2500","position":5,"is_corresponding":false},{"id":1242318,"name":"Qiying Li","orcid":"0000-0001-5056-3221","position":6,"is_corresponding":false},{"id":302236,"name":"Yaling Liu","orcid":"0000-0002-4519-3358","position":7,"is_corresponding":false},{"id":733948,"name":"Yuwen Zhao","orcid":"0000-0001-5020-9134","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T02:00:03.406367Z","pmid":"38652824","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}