{"doi":"10.1021/acsami.2c02523","title":"Therapeutic Effects of Self-Assembled Tetrahedral Framework Nucleic Acids on Liver Regeneration in Acute Liver Failure","abstract":null,"journal":"ACS Applied Materials & Interfaces","year":2022,"id":623641,"datarank":0.9619035435557353,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.4286013343323231,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.4286013343323231,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":19,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1611800,"name":"Sirong Shi","orcid":null,"position":1,"is_corresponding":false},{"id":582684,"name":"Bo Li","orcid":"0000-0001-8782-2485","position":2,"is_corresponding":false},{"id":696431,"name":"Tian Lan","orcid":"0000-0002-4099-5386","position":3,"is_corresponding":false},{"id":1611801,"name":"Kefei Yuan","orcid":null,"position":4,"is_corresponding":false},{"id":1611802,"name":"Jingsheng Yuan","orcid":null,"position":5,"is_corresponding":false},{"id":1611803,"name":"Yongjie Zhou","orcid":null,"position":6,"is_corresponding":false},{"id":1611804,"name":"Jiulin Song","orcid":null,"position":7,"is_corresponding":false},{"id":1611805,"name":"Tao Lv","orcid":null,"position":8,"is_corresponding":false},{"id":1548040,"name":"Yujun Shi","orcid":null,"position":9,"is_corresponding":false},{"id":426554,"name":"Bo Xiang","orcid":"0000-0001-9794-6801","position":10,"is_corresponding":false},{"id":561739,"name":"Taoran Tian","orcid":"0000-0002-8048-0328","position":11,"is_corresponding":false},{"id":714193,"name":"Tao Zhang","orcid":"0000-0003-2765-2802","position":12,"is_corresponding":false},{"id":1526046,"name":"Jiayin Yang","orcid":null,"position":13,"is_corresponding":false},{"id":403965,"name":"Yunfeng Lin","orcid":"0000-0003-1224-6561","position":14,"is_corresponding":false},{"id":674001,"name":"Yang Chen","orcid":"0009-0008-5752-1639","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Therapeutic Effects of Self-Assembled Tetrahedral Framework Nucleic Acids on Liver Regeneration in Acute Liver Failure","abstract":"Liver failure is a serious disease that is characterized by global hepatocyte necrosis. Hepatocyte proliferation and liver regeneration are critically important for the success of treatments for liver disease. Tetrahedral framework nucleic acids (TFNAs), which are widely used antioxidants and anti-inflammatory nanomaterials, activate multiple proliferation and prosurvival pathways. Therefore, the effects of a TFNA on hepatocyte proliferation and liver regeneration in mouse livers injured by 70% partial hepatectomy (PHx), acetaminophen overdose, and carbon tetrachloride were explored in this study. The TFNA, which was successfully self-assembled from four specifically designed ssDNAs, entered the body quickly and was taken up effectively by hepatocytes in the liver and could eventually be cleared by the kidneys. The TFNA promoted hepatocyte proliferation in vitro by activating the Notch and Wnt signaling pathways. In the three in vivo mouse models of liver injury, the TFNA attenuated the injuries and enhanced liver regeneration by regulating the cell cycle and the P53 signaling pathway. Therefore, by promoting hepatocyte proliferation and enhancing liver regeneration, the TFNA shows potential as an effective therapeutic agent for treating acute liver injury induced by 70% PHx and other factors, thereby preventing the progression to acute liver failure and reducing the associated mortality rate.","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35285610","pmcid":null,"openalex_id":"https://openalex.org/W4220920257","authors":[],"funders":[{"funder_name":"National Key R&D Program of China","grant_id":"2019YFA0110600","title":null},{"funder_name":"Open Research Program of National Facility for Translational Medicine","grant_id":"TMSK-2021-204","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82101077, 81970916","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities, Postdoctoral Science Foundation of China","grant_id":"2021M692271, 2020T130443, 2021TQ0224","title":null}],"total_grants":4,"fwci":3.8681,"citation_percentile":0.95184676,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":9},{"year":2024,"count":13},{"year":2025,"count":6},{"year":2026,"count":3}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acsami.2c02523","host_type":"publisher"},{"url":"https://doi.org/10.1021/acsami.2c02523","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35285610","host_type":"repository"}],"fields_of_study":["Liver physiology and pathology","Organ Transplantation Techniques and Outcomes","RNA Interference and Gene Delivery","Medicine","Chemistry"],"mesh_terms":["Animals","Liver","Liver Regeneration","Mice, Inbred C57BL","Nucleic Acids","Liver Failure, Acute","Hepatocytes","Cell Proliferation","Mice","Wnt Signaling Pathway"],"keywords":["Liver regeneration","Hepatocyte","Regeneration (biology)","Liver injury","Wnt signaling pathway","Liver disease","Acetaminophen","In vivo","Cancer research","Cell biology","Biology","Cholestasis","Pharmacology","Signal transduction","In vitro","Biochemistry","Endocrinology","Hepatocyte proliferation","Acute liver injury","Tetrahedral Framework Nucleic Acids (Tfnas)","70 Percent Partial Hepatectomy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T00:42:32.681532Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}