{"doi":"10.1021/acsami.1c18553","title":"Understanding the Photochemical Properties of Polythiophene Polyelectrolyte Soft Aggregates with Sodium Dodecyl Sulfate for Antimicrobial Activity","abstract":"The threat of antibiotic-resistant bacteria is an ever-increasing problem in public health. In this report, we examine the photochemical properties with a proof-of-principle biocidal assay for a novel series of regio-regular imidazolium derivative poly-(3-hexylthiophene)/sodium dodecyl sulfate (P3HT-Im/SDS) materials from ultrafast sub-ps dynamics to μs generation of reactive oxygen species (ROS) and 30 min biocidal reactivity with Escherichia coli (E. coli). This broad series encompassing pure P3HT-Im to cationic, neutral, and anionic P3HT-Im/SDS materials are all interrogated by a variety of techniques to characterize the physical material structure, electronic structure, and antimicrobial activity. Our results show that SDS complexation with P3HT-Im results in aggregate materials with reduced ROS generation and light-induced anti-microbial activity. However, our characterization reveals that the presence of non-aggregated or lightly SDS-covered polymer segments is still capable of ROS generation. Full encapsulation of the P3HT-Im polymer completely deactivates the light killing pathway. High SDS concentrations, near and above critical micelle concentration, further deactivate all anti-microbial activity (light and dark) even though the P3HT-Im regains its electronic properties to generate ROS.","journal":"ACS Applied Materials & Interfaces","year":2021,"id":208645,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":795300,"name":"Jianzhong Yang","orcid":"0000-0001-5482-2382","position":1,"is_corresponding":false},{"id":795301,"name":"Fahimeh Maghsoodi","orcid":"0000-0001-5996-8866","position":2,"is_corresponding":false},{"id":795302,"name":"Andrea Scheberl","orcid":"0000-0001-6545-4714","position":3,"is_corresponding":false},{"id":795303,"name":"Samuel M. Greer","orcid":"0000-0001-8225-3252","position":4,"is_corresponding":false},{"id":795304,"name":"Mohammed I. Khalil","orcid":"0000-0002-9310-2780","position":5,"is_corresponding":false},{"id":795767,"name":"Edward Strach","orcid":null,"position":6,"is_corresponding":false},{"id":795768,"name":"Dylan M. Brown","orcid":null,"position":7,"is_corresponding":false},{"id":430702,"name":"Benjamin W. Stein","orcid":"0000-0002-0366-5476","position":8,"is_corresponding":false},{"id":795305,"name":"Erik Reimhult","orcid":"0000-0003-1417-5576","position":9,"is_corresponding":false},{"id":795306,"name":"Jeffrey J. Rack","orcid":"0000-0001-6121-879X","position":10,"is_corresponding":false},{"id":326011,"name":"Eva Y.","orcid":"0000-0001-7448-9943","position":11,"is_corresponding":false},{"id":328141,"name":"David G. Whitten","orcid":"0000-0002-6305-9494","position":12,"is_corresponding":false},{"id":795299,"name":"Maksim Y. Livshits","orcid":"0000-0003-3601-1230","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T23:51:57.582057Z","pmid":"34788015","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}