{"doi":"10.1021/acsami.0c13230","title":"Nitric Oxide-Releasing Insert for Disinfecting the Hub Region of Tunnel Dialysis Catheters","abstract":"The use of tunneled dialysis catheters (TDCs) for patients in need of hemodialysis treatments (HDs) causes a significant number of bloodstream infections (BSIs), with very few viable preventative/treatment methods. Use of antibiotics is relatively ineffective due to the development of multidrug-resistant bacterial strains and the inability to penetrate bacterial biofilms. Nitric oxide (NO) is an endogenous gas molecule that has broad-spectrum antimicrobial/antibiofilm activity. In this study, the potential of creating a NO-releasing insert device that is attached onto the hub region cap of TDCs and locally releases NO within the TDC hub is evaluated for its antimicrobial/antibiofilm effectiveness. The NO-releasing insert contains the natural NO donor S-nitrosoglutathione (GSNO), along with zinc oxide (ZnO) nanoparticles to accelerate NO release from the GSNO, within a short silicone tube that is sealed at both ends and attached to the catheter cap. An in vitro 3-d-long antimicrobial study using catheter hubs yielded >6.6 log reductions of both Pseudomonas aeruginosa and Staphylococcus aureus for the NO-releasing insert device compared to controls. Two 14-d-long sheep studies demonstrated that the NO-releasing insert devices are exceptionally potent at preventing bacteria/biofilm growth on the inner lumen walls of TDCs compared to controls that have no preventative treatment devices as well as implanted TDCs that have commercially available chlorhexidine-treated insert devices placed within the hub regions.","journal":"ACS Applied Materials & Interfaces","year":2020,"id":71167,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.963,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":376355,"name":"Shale J. Mack","orcid":"0000-0002-0945-7731","position":1,"is_corresponding":false},{"id":377650,"name":"Amy Luo","orcid":null,"position":2,"is_corresponding":false},{"id":376356,"name":"Blake Stringer","orcid":"0009-0005-6149-0861","position":3,"is_corresponding":false},{"id":377651,"name":"Shelby Reno","orcid":null,"position":4,"is_corresponding":false},{"id":377652,"name":"Marie S. Cornell","orcid":null,"position":5,"is_corresponding":false},{"id":376357,"name":"Álvaro Rojas-Peña","orcid":"0000-0002-6197-8892","position":6,"is_corresponding":false},{"id":376358,"name":"Jianfeng Wu","orcid":"0000-0002-9770-5538","position":7,"is_corresponding":false},{"id":376359,"name":"Chuanwu Xi","orcid":"0000-0002-7554-1915","position":8,"is_corresponding":false},{"id":376360,"name":"Alexander S. Yevzlin","orcid":"0000-0001-5213-8376","position":9,"is_corresponding":false},{"id":377653,"name":"Mark E. Meyerhoff","orcid":null,"position":10,"is_corresponding":false},{"id":376354,"name":"Joshua C. Doverspike","orcid":"0000-0002-6062-9607","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T21:43:57.004133Z","pmid":"32931236","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}