{"doi":"10.1021/acsabm.5c00754","title":"Nitric Oxide-Releasing, Hyaluronic Acid-Coated Electrospun Fibers as Dual-Action Wound Dressings","abstract":"Traditional wound dressings are applied to cover and protect a wound from further injury and infection to provide time for healing. Thus, a wound dressing with bioactivity that has pro-wound healing and antibacterial action represents a promising alternative for traditional wound dressings. In this study, a blend of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) was electrospun into fiber mats, coated with hyaluronic acid (HA), and functionalized with N -diazeniumdiolate nitric oxide (NO) donors to develop a dressing capable of clearing bacterial infection and promoting wound healing in vivo. These electrospun fibers were highly porous with uniform diameters and capable of releasing large quantities of NO (∼0.6 μmol mg –1 ) for up to 12 h. The mats displayed swelling capacities of over 300% and resisted degradation up to 10 d, making them useful for long-term wound healing. The NO-releasing electrospun fibers demonstrated potent antibacterial activity against Pseudomonas aeruginosa in vitro and improved bacterial clearance, reduced inflammation, and promoted wound healing in an in vivo punch-biopsy wound model. Together, these data demonstrate that electrospun fibers represent a promising option for use as bioactive wound dressings.","journal":"ACS Applied Bio Materials","year":2025,"id":536503,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1068029,"name":"Samantha L. Picciotti","orcid":null,"position":1,"is_corresponding":false},{"id":1269087,"name":"Anna L. Lynch","orcid":null,"position":2,"is_corresponding":false},{"id":954423,"name":"Taron M. Bradshaw","orcid":null,"position":3,"is_corresponding":false},{"id":1286353,"name":"Darci E. Anderson","orcid":null,"position":4,"is_corresponding":false},{"id":1417578,"name":"Matthew F. Warchol","orcid":null,"position":5,"is_corresponding":false},{"id":1265402,"name":"Madelyn P. Bucci","orcid":null,"position":6,"is_corresponding":false},{"id":551791,"name":"Robert Maile","orcid":"0000-0002-9126-4188","position":7,"is_corresponding":false},{"id":551792,"name":"Shannon M. Wallet","orcid":"0000-0003-4650-651X","position":8,"is_corresponding":false},{"id":394496,"name":"Mark H. Schoenfisch","orcid":"0000-0002-2212-0658","position":9,"is_corresponding":false},{"id":1264518,"name":"Margery E. Purvis","orcid":null,"position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:52:05.227140Z","pmid":"40794539","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}