{"doi":"10.1021/acsabm.3c00219","title":"KCl Nanoparticles as Potential Inducer of Immunogenic Cell Death for Cancer Immunotherapy","abstract":null,"journal":"ACS Applied Bio Materials","year":2023,"id":600151,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":527194,"name":"Xiaohong Zhang","orcid":"0000-0002-6732-2499","position":1,"is_corresponding":false},{"id":57807,"name":"Yang Luo","orcid":"0000-0001-7385-6166","position":2,"is_corresponding":false},{"id":710398,"name":"Yi Wang","orcid":"0000-0001-8043-4869","position":3,"is_corresponding":false},{"id":1337139,"name":"Shaobing Zhou","orcid":"0000-0002-6155-4010","position":4,"is_corresponding":false},{"id":1538413,"name":"Zhengjie Huang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"KCl Nanoparticles as Potential Inducer of Immunogenic Cell Death for Cancer Immunotherapy","abstract":"Immunogenic cell death (ICD) is a promising cancer immunotherapy by inducing antigen-presenting cell maturation. Many inorganic nanomodulators have been developed for cancer therapy via ion overload, and their ICD-inducing properties have also been explored for immunotherapy. Here, we report a potassium chloride nanoparticle (PCNP)-loaded poly(lactic- co -glycolic acid) nanoparticle coated with cancer cell membrane (PC@P-CCM) for cancer therapy. Through cancer cell membrane (CCM)-achieved surface functionalization, the homotypic targeting behaviors of PC@P-CCM are dramatically enhanced. Once internalized by cancer cells, the PC@P-CCM could be degraded in acidic lysosomes, thus releasing K + and Cl – ions. These ions can change the osmotic pressure of cancer cells, causing a hypertonic state in the cancer cells in a short time and leading to the rupture and death of cancer cells. Furthermore, these ions can stimulate cancer cells to secrete adenosine triphosphate (ATP) and high mobility group box 1 (HMGB-1); meanwhile, calreticulin (CRT) showed increased presentation on the surface of cancer cells, which can further induce dendritic cell maturation and promote the immunotherapy. This work provides a new perspective on KCl nanoparticle-based cancer immunotherapy.","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37192493","pmcid":null,"openalex_id":"https://openalex.org/W4376637384","authors":[],"funders":[{"funder_name":"National Key Research and Development Program of China","grant_id":"2021YFB3800900","title":null},{"funder_name":"Department of Science and Technology of Sichuan Province","grant_id":"2020YFH0052","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"2682019CX76","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"52033007","title":null}],"total_grants":4,"fwci":1.2267,"citation_percentile":0.77730899,"influential_citations":0,"citation_trend":[{"year":2024,"count":6},{"year":2025,"count":6},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.3c00219","host_type":"publisher"},{"url":"https://doi.org/10.1021/acsabm.3c00219","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37192493","host_type":"repository"}],"fields_of_study":["RNA Interference and Gene Delivery","Nanoparticle-Based Drug Delivery","Immunotherapy and Immune Responses"],"mesh_terms":["Immunogenic Cell Death","Humans","Immunotherapy","Neoplasms","Potassium Chloride","Nanoparticles"],"keywords":["Cancer immunotherapy","Inducer","Immunotherapy","Immunogenic cell death","Cancer","Programmed cell death","Nanoparticle","Cancer research","Immunology","Medicine","Chemistry","Apoptosis","Nanotechnology","Materials science","Internal medicine","Biochemistry","tumor immunotherapy","Icd","Ph-responsive","Immunogenic Death","Potassium Chloride Nanoparticles","Pcnps","Bionic Nanoparticle","Endocellular Ion Nanomodulators"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T12:21:45.790772Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}