{"doi":"10.1021/acs.orglett.4c04013","title":"Total Synthesis of Marformycins A and D","abstract":"We report the synthesis of the antimicrobial cyclodepsipeptides marformycin A ( 1 ) and marformycin D ( 2 ) using a solid-phase approach. A scalable solution-phase synthesis of the γ-hydroxypiperazic acid subunit in 2, starting from cis -hydroxyproline, is also described. Structural analysis of 1 and its Leu- epi congener demonstrates conformational differences that may underlie their divergent antimicrobial activities. The described approach enables further development of conformation–activity relationships within this class of depsipeptide natural products.","journal":"Organic Letters","year":2024,"id":452411,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":948898,"name":"Yassin M. Elbatrawi","orcid":null,"position":1,"is_corresponding":false},{"id":948437,"name":"David Degen","orcid":"0000-0002-2916-0564","position":2,"is_corresponding":false},{"id":506449,"name":"Richard H. Ebright","orcid":"0000-0001-8915-7140","position":3,"is_corresponding":false},{"id":384769,"name":"Juan R. Del Valle","orcid":"0000-0002-7964-8402","position":4,"is_corresponding":false},{"id":948900,"name":"Avraz F. Anwar","orcid":null,"position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:02:50.407779Z","pmid":"39531363","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}