{"doi":"10.1021/acs.orglett.3c03499","title":"On the Risk of <sup>18</sup>F-Regioisomer Formation in the Copper-Free Radiofluorination of Aryliodonium Precursors","abstract":"Aryliodonium precursors are widely applied for copper-free labeling of positron emission tomography (PET) tracers with fluorine-18. We assessed 18 F-fluoroarene regioisomer formation in examples of these labeling methods. Aryliodonium ylides derived from Meldrum’s acid bearing para electron-donating groups react with [ 18 F]fluoride in acetonitrile to produce regioisomeric 18 F-fluoroarenes via a competing aryne pathway. Regioisomer formation is decreased or absent in DMF. Analytically checking for the absence of the 18 F-regioisomer from any particular PET tracer radiosynthesis using these or similar methods is recommended.","journal":"Organic Letters","year":2023,"id":378076,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":817910,"name":"Jean M. Etersque","orcid":"0000-0002-1206-2239","position":1,"is_corresponding":false},{"id":399701,"name":"Shuiyu Lu","orcid":"0000-0003-0310-4318","position":2,"is_corresponding":false},{"id":348139,"name":"Sanjay Telu","orcid":"0000-0001-5300-8725","position":3,"is_corresponding":false},{"id":342697,"name":"Victor W. Pike","orcid":"0000-0001-9032-2553","position":4,"is_corresponding":false},{"id":1067739,"name":"Qunchao Zhao","orcid":"0000-0001-8999-7713","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T01:16:44.708019Z","pmid":"38012005","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}