{"doi":"10.1021/acs.orglett.3c01396","title":"[3 + 2] Cycloadditions of Tertiary Amine <i>N</i>-Oxides and Silyl Imines as an Innovative Route to 1,2-Diamines","abstract":"We have developed a one-pot synthetic method for producing 1,2-diamines from easily prepared and commercially available precursors through a formal umpolung process. Our method utilizes an efficient [3 + 2] cycloaddition as the key step in forming substituted 1,2-diamines in moderate to high yields. These resulting compounds can undergo subsequent transformations, demonstrating their utility as synthetic building blocks for more complex scaffolds. Finally, we propose a reasonable mechanism for this transformation using density functional theory modeling, justifying the experimental observations.","journal":"Organic Letters","year":2023,"id":364078,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1119338,"name":"Danielle R. Beres","orcid":null,"position":1,"is_corresponding":false},{"id":1118831,"name":"Alexander H. Cocolas","orcid":"0000-0003-2684-9355","position":2,"is_corresponding":false},{"id":1118832,"name":"Martin J. Neal","orcid":"0000-0002-9767-361X","position":3,"is_corresponding":false},{"id":1118833,"name":"Benjamin S. Musiak","orcid":"0000-0002-9907-3837","position":4,"is_corresponding":false},{"id":1118834,"name":"Marianne M. B. Hanna","orcid":"0000-0002-0745-0050","position":5,"is_corresponding":false},{"id":1118835,"name":"Aaron Bloomfield","orcid":"0000-0001-9805-2308","position":6,"is_corresponding":false},{"id":1118836,"name":"Thomas D. Montgomery","orcid":"0000-0002-6526-8564","position":7,"is_corresponding":false},{"id":1118830,"name":"Sarah L. Hejnosz","orcid":"0009-0004-8742-286X","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T01:14:36.728255Z","pmid":"37318514","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}