{"doi":"10.1021/acs.orglett.2c03940","title":"Direct C–H Radiocyanation of Arenes via Organic Photoredox Catalysis","abstract":"Innovative labeling methods to incorporate the short-lived positron emitter carbon-11(11C) into bioactive molecules are attractive for positron emission tomography (PET) tracer discovery. Herein, we report a direct C–H radiocyanation method that incorporates [11C]cyanide (11CN–) to a series of functional electron-rich arenes via photoredox catalysis. This photoredox-mediated radiocyanation can proceed in an aerobic environment and is not moisture sensitive, which allows for ease of reaction setup and for scalable synthesis of 11C-aryl nitriles from readily available precursors.","journal":"Organic Letters","year":2022,"id":252220,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.948,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":726823,"name":"Xuedan Wu","orcid":"0000-0001-5875-4233","position":1,"is_corresponding":false},{"id":299835,"name":"Joshua B. McManus","orcid":null,"position":2,"is_corresponding":false},{"id":896666,"name":"Gerald Thomas Bida","orcid":null,"position":3,"is_corresponding":false},{"id":573276,"name":"Kang-Po Li","orcid":null,"position":4,"is_corresponding":false},{"id":504470,"name":"Zhanhong Wu","orcid":"0000-0002-3528-5603","position":5,"is_corresponding":false},{"id":297207,"name":"David A. Nicewicz","orcid":"0000-0003-1199-9879","position":6,"is_corresponding":false},{"id":258567,"name":"Zibo Li","orcid":"0000-0002-1063-0298","position":7,"is_corresponding":false},{"id":572739,"name":"Wei Chen","orcid":"0000-0002-3694-5204","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T00:24:46.226372Z","pmid":"36507797","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}