{"doi":"10.1021/acs.oprd.2c00388","title":"Strategies for the Production of [<sup>11</sup>C]LY2795050 for Clinical Use","abstract":"This report describes a comparison of four different routes for the clinical-scale radiosynthesis of the κ-opioid receptor antagonist [ 11 C]LY2795050. Palladium-mediated radiocyanation and radiocarbonylation of an aryl iodide precursor, as well as copper-mediated radiocyanation of an aryl iodide and an aryl boronate ester, have been investigated. Full automation of all four methods is reported, each of which provides [ 11 C]LY2795050 in sufficient radiochemical yield, molar activity, and radiochemical purity for clinical use. The advantages and disadvantages of each radiosynthesis method are compared and contrasted.","journal":"Organic Process Research & Development","year":2023,"id":361687,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1045483,"name":"Xia Shao","orcid":"0000-0002-7291-2477","position":1,"is_corresponding":false},{"id":1099371,"name":"Mami Horikawa","orcid":"0000-0001-6317-0689","position":2,"is_corresponding":false},{"id":1099372,"name":"Liam S. Sharninghausen","orcid":"0000-0002-2249-1010","position":3,"is_corresponding":false},{"id":1114926,"name":"Sean Preshlock","orcid":null,"position":4,"is_corresponding":false},{"id":350841,"name":"Allen F. Brooks","orcid":"0000-0003-3773-3024","position":5,"is_corresponding":false},{"id":352215,"name":"Bradford D. Henderson","orcid":null,"position":6,"is_corresponding":false},{"id":226060,"name":"Robert A. Koeppe","orcid":"0000-0002-9514-5311","position":7,"is_corresponding":false},{"id":496172,"name":"Alexandre F. DaSilva","orcid":"0000-0003-3138-7781","position":8,"is_corresponding":false},{"id":350845,"name":"Melanie S. Sanford","orcid":"0000-0001-9342-9436","position":9,"is_corresponding":false},{"id":342700,"name":"Peter J. H. Scott","orcid":"0000-0002-6505-0450","position":10,"is_corresponding":false},{"id":754719,"name":"Tanpreet Kaur","orcid":"0000-0002-4700-3116","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T01:14:15.063476Z","pmid":"36874204","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}