{"doi":"10.1021/acs.jproteome.3c00357","title":"Evaluating the Performance of the Astral Mass Analyzer for Quantitative Proteomics Using Data-Independent Acquisition","abstract":"We evaluate the quantitative performance of the newly released Asymmetric Track Lossless (Astral) analyzer. Using data-independent acquisition, the Thermo Scientific Orbitrap Astral mass spectrometer quantifies 5 times more peptides per unit time than state-of-the-art Thermo Scientific Orbitrap mass spectrometers, which have long been the gold standard for high-resolution quantitative proteomics. Our results demonstrate that the Orbitrap Astral mass spectrometer can produce high-quality quantitative measurements across a wide dynamic range. We also use a newly developed extracellular vesicle enrichment protocol to reach new depths of coverage in the plasma proteome, quantifying over 5000 plasma proteins in a 60 min gradient with the Orbitrap Astral mass spectrometer.","journal":"Journal of Proteome Research","year":2023,"id":315076,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":231,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1014929,"name":"Eugen Damoc","orcid":"0000-0002-4422-2866","position":1,"is_corresponding":false},{"id":1014930,"name":"Tabiwang N. Arrey","orcid":"0009-0001-2888-2055","position":2,"is_corresponding":false},{"id":1015698,"name":"Anna Pashkova","orcid":null,"position":3,"is_corresponding":false},{"id":1015699,"name":"Eduard Denisov","orcid":null,"position":4,"is_corresponding":false},{"id":1015700,"name":"J. Petzoldt","orcid":null,"position":5,"is_corresponding":false},{"id":1015701,"name":"Amelia C. Peterson","orcid":null,"position":6,"is_corresponding":false},{"id":1014931,"name":"Chris Hsu","orcid":"0000-0002-0846-6126","position":7,"is_corresponding":false},{"id":237002,"name":"Brian C. Searle","orcid":"0000-0001-8760-6731","position":8,"is_corresponding":false},{"id":668121,"name":"Nicholas Shulman","orcid":"0000-0003-1674-0794","position":9,"is_corresponding":false},{"id":912599,"name":"Michael Riffle","orcid":"0000-0003-1633-8607","position":10,"is_corresponding":false},{"id":1014932,"name":"B. Connolly","orcid":"0000-0001-7084-4311","position":11,"is_corresponding":false},{"id":110395,"name":"Brendan MacLean","orcid":"0000-0002-9575-0255","position":12,"is_corresponding":false},{"id":473983,"name":"Philip M. Remes","orcid":"0000-0003-0567-4541","position":13,"is_corresponding":false},{"id":247293,"name":"Michael W. Senko","orcid":"0009-0000-5040-5776","position":14,"is_corresponding":false},{"id":1014933,"name":"Hamish Stewart","orcid":"0009-0000-1510-4353","position":15,"is_corresponding":false},{"id":1015702,"name":"Christian Hock","orcid":null,"position":16,"is_corresponding":false},{"id":247291,"name":"Alexander Makarov","orcid":"0000-0002-7046-6709","position":17,"is_corresponding":false},{"id":1015703,"name":"Daniel Hermanson","orcid":null,"position":18,"is_corresponding":false},{"id":247290,"name":"Vlad Zabrouskov","orcid":"0000-0003-3567-9407","position":19,"is_corresponding":false},{"id":344297,"name":"Christine C. Wu","orcid":"0009-0000-6518-8487","position":20,"is_corresponding":false},{"id":79569,"name":"Michael J. MacCoss","orcid":"0000-0003-1853-0256","position":21,"is_corresponding":false},{"id":684559,"name":"Lilian R. Heil","orcid":"0000-0002-9462-7327","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T01:06:02.898877Z","pmid":"37683181","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}