{"doi":"10.1021/acs.jproteome.3c00196","title":"Proteogenomics in Cancer: Then and Now","abstract":null,"journal":"Journal of Proteome Research","year":2023,"id":608956,"datarank":0.390120462275039,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.060536775674606046,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.060536775674606046,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":8,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1564702,"name":"Yan-Ming Xu","orcid":"0000-0003-1124-0045","position":1,"is_corresponding":false},{"id":530054,"name":"Andy T. Y. Lau","orcid":"0000-0002-7146-7789","position":2,"is_corresponding":false},{"id":1564701,"name":"Xiu-Yun Wang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Proteogenomics in Cancer: Then and Now","abstract":"For years, the paths of sequencing technologies and mass spectrometry have occurred in isolation, with each developing its own unique culture and expertise. These two technologies are crucial for inspecting complementary aspects of the molecular phenotype across the central dogma. Integrative multiomics strives to bridge the analysis gap among different fields to complete more comprehensive mechanisms of life events and diseases. Proteogenomics is one integrated multiomics field. Here in this review, we mainly summarize and discuss three aspects: workflow of proteogenomics, proteogenomics applications in cancer research, and the SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis of proteogenomics in cancer research. In conclusion, proteogenomics has a promising future as it clarifies the functional consequences of many unannotated genomic abnormalities or noncanonical variants and identifies driver genes and novel therapeutic targets across cancers, which would substantially accelerate the development of precision oncology.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37725793","pmcid":null,"openalex_id":"https://openalex.org/W4386856376","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"31271445","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"31771582","title":null},{"funder_name":"Natural Science Foundation of Guangdong Province","grant_id":"2017A030313131","title":null},{"funder_name":"Shantou Medical Health Science and Technology Plan","grant_id":"200624165260857","title":null},{"funder_name":"Basic and Applied Research Major Projects of Guangdong Province","grant_id":"2017KZDXM035","title":null},{"funder_name":"Basic and Applied Research Major Projects of Guangdong Province","grant_id":"2018KZDXM036","title":null},{"funder_name":"?Yang Fan? Project of Guangdong Province of China","grant_id":"","title":null},{"funder_name":"Department of Education of Guangdong Province","grant_id":"","title":null}],"total_grants":8,"fwci":0.8764,"citation_percentile":0.6789511,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.3c00196","host_type":"publisher"},{"url":"https://doi.org/10.1021/acs.jproteome.3c00196","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37725793","host_type":"repository"}],"fields_of_study":["Advanced Proteomics Techniques and Applications","Bioinformatics and Genomic Networks","Proteogenomics","Humans","Neoplasms","Mass Spectrometry","Precision Medicine"],"mesh_terms":["Proteogenomics","Humans","Neoplasms","Mass Spectrometry","Precision Medicine"],"keywords":["Proteogenomics","Computational biology","Biology","Proteomics","Workflow","Genomics","Bioinformatics","Genome","Computer science","Genetics","Gene","Database","Cancer","Swot Analysis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Responsible consumption and production"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T01:11:36.145747Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}