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While adding genetic variants to the search database remains indispensable for correct peptide identification, inclusion of long-read RNA sequences in the search database contributes only 0.3% new peptide identifications. These findings reveal the differences in SAAV detection that result from various approaches, providing guidance to researchers studying SAAV peptides and developers of peptide spectrum identification tools.","is_dataset_classified":null,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33998808","pmcid":"PMC8280751","openalex_id":"https://openalex.org/W3112159008","authors":[],"funders":[{"funder_name":"Radboud Universitair Medisch Centrum","grant_id":"","title":null}],"total_grants":1,"fwci":1.1659,"citation_percentile":0.7463227,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":3},{"year":2025,"count":6},{"year":2026,"count":2}],"oa_status":"bronze","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.1c00264","host_type":"journal"},{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.1c00264","host_type":"publisher"},{"url":"https://doi.org/10.1021/acs.jproteome.1c00264","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33998808","host_type":"repository"},{"url":"https://biblio.ugent.be/publication/8708343","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8280751","host_type":"repository"},{"url":"https://repository.ubn.ru.nl/handle/2066/235044","host_type":"repository"},{"url":"http://hdl.handle.net/2066/235044","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8280751","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8280751?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Advanced Proteomics Techniques and Applications","Machine Learning in Bioinformatics","Genomics and Phylogenetic Studies","Amino Acids","Databases, Protein","Proteogenomics","Proteome","Proteomics","Search Engine"],"mesh_terms":["Proteogenomics","Amino Acids","Proteome","Databases, Protein","Proteomics","Search Engine"],"keywords":["Proteogenomics","Shotgun proteomics","Database search engine","Proteomics","Computational biology","Proteome","Identification (biology)","Shotgun","Computer science","Human proteome project","Biology","Search engine","Bioinformatics","Genomics","Information retrieval","Genome","Gene","Genetics","Direct Rna Sequencing","Open Search","Deep Proteomics","Long-read Rna Sequence"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T08:17:42.749455Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}