{"doi":"10.1021/acs.jpclett.3c02790","title":"Liquid–Liquid Phase Separation of the Intrinsically Disordered Domain of the Fused in Sarcoma Protein Results in Substantial Slowing of Hydration Dynamics","abstract":"Formation of liquid condensates plays a critical role in biology via localization of different components or via altered hydrodynamic transport, yet the hydrogen-bonding environment within condensates, pivotal for solvation, has remained elusive. We explore the hydrogen-bond dynamics within condensates formed by the low-complexity domain of the fused in sarcoma protein. Probing the hydrogen-bond dynamics sensed by condensate proteins using two-dimensional infrared spectroscopy of the protein amide I vibrations, we find that frequency-frequency correlations of the amide I vibration decay on a picosecond time scale. Interestingly, these dynamics are markedly slower for proteins in the condensate than in a homogeneous protein solution, indicative of different hydration dynamics. All-atom molecular dynamics simulations confirm that lifetimes of hydrogen-bonds between water and the protein are longer in the condensates than in the protein in solution. Altered hydrogen-bonding dynamics may contribute to unique solvation and reaction dynamics in such condensates.","journal":"The Journal of Physical Chemistry Letters","year":2023,"id":329800,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9449,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1052990,"name":"Daniel Chávez","orcid":"0000-0002-2061-9455","position":1,"is_corresponding":false},{"id":660665,"name":"Sayantan Chatterjee","orcid":"0000-0003-3791-3463","position":2,"is_corresponding":false},{"id":1052991,"name":"Lukas S. Stelzl","orcid":"0000-0002-5348-0277","position":3,"is_corresponding":false},{"id":782167,"name":"Sabine Pütz","orcid":null,"position":4,"is_corresponding":false},{"id":1052992,"name":"Steven J. Roeters","orcid":"0000-0003-3238-2181","position":5,"is_corresponding":false},{"id":1052993,"name":"Joseph F. Rudzinski","orcid":"0000-0003-3403-640X","position":6,"is_corresponding":false},{"id":303973,"name":"Nicolas L. Fawzi","orcid":"0000-0001-5483-0577","position":7,"is_corresponding":false},{"id":1052994,"name":"Martin Girard","orcid":"0000-0003-2051-6218","position":8,"is_corresponding":false},{"id":140050,"name":"Sapun H. Parekh","orcid":"0000-0001-8522-1854","position":9,"is_corresponding":false},{"id":1052995,"name":"Johannes Hunger","orcid":"0000-0002-4419-5220","position":10,"is_corresponding":false},{"id":1052989,"name":"Carola S. Krevert","orcid":"0000-0001-7339-2306","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T01:09:05.843139Z","pmid":"38056002","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}