{"doi":"10.1021/acs.jpcc.3c01128","title":"LIGHT-SABRE Hyperpolarizes 1-<sup>13</sup>C-Pyruvate Continuously without Magnetic Field Cycling","abstract":"High Resolution Image Download MS PowerPoint Slide Nuclear spin hyperpolarization enables real-time observation of metabolism and intermolecular interactions in vivo . 1- 13 C-pyruvate is the leading hyperpolarized tracer currently under evaluation in several clinical trials as a promising molecular imaging agent. Still, the quest for a simple, fast, and efficient hyperpolarization technique is ongoing. Here, we describe that continuous, weak irradiation in the audio-frequency range of the 13 C spin at the 121 μT magnetic field (approximately twice Earth’s field) enables spin order transfer from parahydrogen to 13 C magnetization of 1- 13 C-pyruvate. These so-called LIGHT-SABRE pulses couple nuclear spin states of parahydrogen and pyruvate via the J -coupling network of reversibly exchanging Ir-complexes. Using ∼100% parahydrogen at ambient pressure, we polarized 51 mM 1- 13 C-pyruvate in the presence of 5.1 mM Ir-complex continuously and repeatedly to a polarization of 1.1% averaged over free and catalyst-bound pyruvate. The experiments were conducted at −8 °C, where almost exclusively bound pyruvate was observed, corresponding to an estimated 11% polarization on bound pyruvate. The obtained hyperpolarization levels closely match those obtained via SABRE-SHEATH under otherwise identical conditions. The creation of three different types of spin orders was observed: transverse 13 C magnetization along the applied magnetic field, 13 C z -magnetization along the main field B 0, and 13 C– 1 H zz -spin order. With a superconducting quantum interference device (SQUID) for detection, we found that the generated spin orders result from 1 H– 13 C J -coupling interactions, which are not visible even with our narrow linewidth below 0.3 Hz and at −8 °C.","journal":"The Journal of Physical Chemistry C","year":2023,"id":331170,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1055994,"name":"Kai Buckenmaier","orcid":"0000-0002-9676-443X","position":1,"is_corresponding":false},{"id":1055995,"name":"Nicolas Kempf","orcid":"0009-0003-7334-084X","position":2,"is_corresponding":false},{"id":1055996,"name":"Gabriele Stevanato","orcid":"0000-0003-0020-1286","position":3,"is_corresponding":false},{"id":384838,"name":"Klaus Scheffler","orcid":"0000-0001-6316-8773","position":4,"is_corresponding":false},{"id":1055997,"name":"J Engelmann","orcid":"0000-0002-6985-4464","position":5,"is_corresponding":false},{"id":1055998,"name":"Markus Plaumann","orcid":"0000-0002-6295-3320","position":6,"is_corresponding":false},{"id":1056646,"name":"Rainer Koerber","orcid":null,"position":7,"is_corresponding":false},{"id":851671,"name":"Jan-Bernd Hövener","orcid":"0000-0001-7255-7252","position":8,"is_corresponding":false},{"id":477788,"name":"Thomas Theis","orcid":"0000-0001-6779-9978","position":9,"is_corresponding":false},{"id":1055993,"name":"Andrey N. Pravdivtsev","orcid":"0000-0002-8763-617X","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T01:09:19.317824Z","pmid":"37081994","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}