{"doi":"10.1021/acs.jpcb.9b07903","title":"Stabilization of Solvent to α-Sheet Structure and Conversion between α-Sheet and β-Sheet in the Fibrillation Process of Amyloid Peptide","abstract":null,"journal":"The Journal of Physical Chemistry B","year":2019,"id":622282,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":607031,"name":"Tong Lu","orcid":"0000-0002-1802-3302","position":1,"is_corresponding":false},{"id":108153,"name":"Fei Li","orcid":"0000-0003-0720-3129","position":2,"is_corresponding":false},{"id":1607734,"name":"Feihong Meng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Stabilization of Solvent to α-Sheet Structure and Conversion between α-Sheet and β-Sheet in the Fibrillation Process of Amyloid Peptide","abstract":"α-sheet conformation has been proposed to exist as an intermediate conformational component and mediate the fibrillar assemblies of amyloid proteins at certain conditions. However, less attention has been paid to this form of conformation in the studies of the mechanism of amyloidosis because there is insufficient evidence for the existence of the α-sheet intermediate and the transition from the α-sheet intermediate to the β-sheet fibril. Herein, we characterized the structures of a d,l-alternating amyloidogenic decapeptide under different conditions and studied the structural conversion between the α-sheet and β-sheet in the fibrillation processes of the peptide. We obtained for the first time the image of α-sheet structured fibrils in aqueous solution and found the essential role of water molecules in the stabilization of the α-sheet structure. We also provided experimental evidence of the structural conversion from the α-sheet to the β-sheet in the peptide aggregates.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31642684","pmcid":null,"openalex_id":"https://openalex.org/W2981608091","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"21673099","title":null}],"total_grants":1,"fwci":0.4554,"citation_percentile":0.60967023,"influential_citations":0,"citation_trend":[{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.9b07903","host_type":"publisher"},{"url":"https://doi.org/10.1021/acs.jpcb.9b07903","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31642684","host_type":"repository"}],"fields_of_study":["Protein Structure and Dynamics","Enzyme Structure and Function","Supramolecular Self-Assembly in Materials","Humans","Hydrogen Bonding","Hydrogen-Ion Concentration","Islet Amyloid Polypeptide","Peptide Fragments","Protein Conformation, beta-Strand","Protein Multimerization","Water"],"mesh_terms":["Protein Conformation, beta-Strand","Humans","Hydrogen Bonding","Hydrogen-Ion Concentration","Peptide Fragments","Water","Protein Multimerization","Islet Amyloid Polypeptide"],"keywords":["Beta sheet","Fibril","Peptide","Amyloid fibril","Amyloid (mycology)","Chemistry","Biophysics","Materials science","Biochemistry","Amyloid β","Biology","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T18:59:01.165607Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}