{"doi":"10.1021/acs.joc.6c00442","title":"Dmpic as an Orthogonal Protecting Group for Aspartic Acid Side Chains: Facilitating the Synthesis of Lactam-Cyclized Peptides","abstract":null,"journal":"The Journal of Organic Chemistry","year":2026,"id":654492,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1708117,"name":"Hanxi Bai","orcid":null,"position":1,"is_corresponding":false},{"id":1708118,"name":"Farong Ye","orcid":null,"position":2,"is_corresponding":false},{"id":1708119,"name":"Kommuru Goutham","orcid":null,"position":3,"is_corresponding":false},{"id":1708120,"name":"Dalovai Purnachandar","orcid":null,"position":4,"is_corresponding":false},{"id":1708121,"name":"Chanjuan Liu","orcid":"0000-0001-9256-007X","position":5,"is_corresponding":false},{"id":771269,"name":"Ping Huang","orcid":"0000-0003-1775-029X","position":6,"is_corresponding":false},{"id":302967,"name":"Ping Wang","orcid":"0000-0002-8640-1483","position":7,"is_corresponding":false},{"id":672629,"name":"Bin Liu","orcid":"0000-0001-7890-7612","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dmpic as an Orthogonal Protecting Group for Aspartic Acid Side Chains: Facilitating the Synthesis of Lactam-Cyclized Peptides","abstract":"Orthogonal protection of the Asp side chain is critical in peptide synthesis. We introduce the 2-pyridyl isopropyl (Dmpic) group as a photolabile protecting group for the Asp side-chain carboxyl functionality. Dmpic demonstrates excellent stability under both strongly acidic and basic conditions, effectively suppresses aspartimide formation, and can be removed under mild conditions, facilitating the efficient synthesis of diverse Asp-containing lactam-cyclized peptides. Moreover, Dmpic exhibits excellent orthogonality with common protecting groups, offering a straightforward strategy for the synthesis of Asp-containing lactam-cyclized peptides.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42059347","pmcid":null,"openalex_id":"https://openalex.org/W7158720857","authors":[],"funders":[{"funder_name":"Shanghai Jiao Tong University","grant_id":"20230102","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2024YFA1306300","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22225701","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22477078","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"92253302","title":null},{"funder_name":"State Key Laboratory of Synergistic Chem-Bio Synthesis","grant_id":"sklscbs202523","title":null},{"funder_name":"State Key Laboratory of Synergistic Chem-Bio Synthesis","grant_id":"sklscbs202573","title":null},{"funder_name":"Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target","grant_id":"24dz2261300","title":null},{"funder_name":"Shanghai Municipal Science and Technology Major Project","grant_id":"","title":null}],"total_grants":9,"fwci":3.8362,"citation_percentile":0.93462607,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.6c00442","host_type":"publisher"},{"url":"https://doi.org/10.1021/acs.joc.6c00442","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42059347","host_type":"repository"}],"fields_of_study":["Chemical Synthesis and Analysis","Photochromic and Fluorescence Chemistry","Click Chemistry and Applications"],"mesh_terms":["Aspartic Acid","Cyclization","Lactams","Peptides","Peptides, Cyclic","Pyridines","Molecular Structure"],"keywords":["Protecting group","Isopropyl","Orthogonality","Peptide synthesis","Side chain","Group (periodic table)"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T06:56:28.337403Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}