{"doi":"10.1021/acs.joc.4c02828","title":"Potent Analogues of Clovibactin from Commercially Available Amino Acid Building Blocks","abstract":"High Resolution Image Download MS PowerPoint Slide This paper reports highly active analogues of clovibactin in which the rare, noncanonical amino acid d -hydroxyasparagine is replaced with the commercially available amino acid d -threonine. Sequential mutation of leucines 2, 7, and 8 to the more hydrophobic homologue cyclohexylalanine dramatically increases the antibiotic activity of d -Thr 5 -clovibactin. The resulting analogues ( d -Cha 2, d -Thr 5 -clovibactin, Cha 7, d -Thr 5 -clovibactin, and Cha 8, d -Thr 5 -clovibactin) are readily prepared by standard peptide synthesis techniques and exhibit excellent activity (≤1 μg/mL) against the Gram-positive, drug-resistant pathogens MRSA and VRE.","journal":"The Journal of Organic Chemistry","year":2025,"id":529898,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9494,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1261782,"name":"Jeramiah Small","orcid":null,"position":1,"is_corresponding":false},{"id":1297565,"name":"Maria Sophia Teresa Lee Padilla","orcid":null,"position":2,"is_corresponding":false},{"id":1339462,"name":"Jovanna I. Carrera Plancarte","orcid":null,"position":3,"is_corresponding":false},{"id":168285,"name":"James S. Nowick","orcid":"0000-0002-2273-1029","position":4,"is_corresponding":false},{"id":1261282,"name":"Jackson E. H. Brunicardi","orcid":"0000-0002-3661-9476","position":0,"is_corresponding":true}],"reference_count":8,"raw_metadata":null,"created_at":"2026-07-19T02:51:01.235017Z","pmid":"39865672","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}