{"doi":"10.1021/acs.jnatprod.7b00866","title":"Exploration of Fungal Metabolic Interactions Using Imaging Mass Spectrometry on Nanostructured Silicon","abstract":null,"journal":"Journal of Natural Products","year":2018,"id":610981,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1571108,"name":"Chi-Ying Hsieh","orcid":null,"position":1,"is_corresponding":false},{"id":1571109,"name":"Chao-Jen Shih","orcid":null,"position":2,"is_corresponding":false},{"id":1571110,"name":"Yuan-Jing Lin","orcid":null,"position":3,"is_corresponding":false},{"id":1535315,"name":"Chia-Wen Tsao","orcid":null,"position":4,"is_corresponding":false},{"id":261986,"name":"Yuliang Yang","orcid":"0000-0002-3533-5148","position":5,"is_corresponding":false},{"id":1571107,"name":"Pi-Yu Chen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Exploration of Fungal Metabolic Interactions Using Imaging Mass Spectrometry on Nanostructured Silicon","abstract":"Application of matrix-assisted laser desorption/ionization imaging mass spectrometry to microbiology and natural product research has opened the door to the exploration of microbial interactions and the consequent discovery of new natural products and their functions in the interactions. However, several drawbacks of matrix-assisted laser desorption/ionization imaging mass spectrometry have limited its application especially to complicated and uneven microbial samples. Here, we applied nanostructured silicon as a substrate for surface-assisted laser desorption/ionization mass spectrometry for microbial imaging mass spectrometry to explore fungal metabolic interactions. We chose Phellinus noxius and Aspergillus strains to evaluate the potential of microbial imaging mass spectrometry on nanostructured silicon because both fungi produce a dense mass of aerial mycelia, which is known to complicate the collection of high-quality imaging mass spectrometry data. Our simple and straightforward sample imprinting method and low background interference resulted in an efficient analysis of small metabolites from the complex microbial interaction samples.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29916245","pmcid":null,"openalex_id":"https://openalex.org/W2809209109","authors":[],"funders":[{"funder_name":"Ministry of Science and Technology, Taiwan","grant_id":"MOST 104-2320-B-001-019-MY2","title":null}],"total_grants":1,"fwci":1.031,"citation_percentile":0.71896177,"influential_citations":0,"citation_trend":[{"year":2019,"count":4},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":4},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.7b00866","host_type":"publisher"},{"url":"https://doi.org/10.1021/acs.jnatprod.7b00866","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29916245","host_type":"repository"}],"fields_of_study":["Mass Spectrometry Techniques and Applications","Advanced Proteomics Techniques and Applications","Ion-surface interactions and analysis"],"mesh_terms":["Aspergillus","Basidiomycota","Silicon","Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","Nanostructures"],"keywords":["Mass spectrometry","Mass spectrometry imaging","MALDI imaging","Chemistry","Orbitrap","Matrix-assisted laser desorption/ionization","Analytical Chemistry (journal)","Desorption","Chromatography","Organic chemistry","Adsorption"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Responsible consumption and production"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T13:59:33.491221Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}