{"doi":"10.1021/acs.jnatprod.6c00169","title":"Barettin, a Nonopioid, Nonhallucinogenic Marine Natural Product with Antihyperalgesic Properties Mediated by 5HT2A Inverse Agonism","abstract":null,"journal":"Journal of Natural Products","year":2026,"id":627310,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1623548,"name":"Michael Okine","orcid":null,"position":1,"is_corresponding":false},{"id":1623549,"name":"Emily G. Forrest","orcid":"0009-0005-6619-9299","position":2,"is_corresponding":false},{"id":1126158,"name":"Timothy Chavez","orcid":"0009-0004-1239-4817","position":3,"is_corresponding":false},{"id":1167825,"name":"Alexandra Stump","orcid":"0000-0003-4361-0610","position":4,"is_corresponding":false},{"id":1623550,"name":"Vishal Kaleeswaran","orcid":null,"position":5,"is_corresponding":false},{"id":1236328,"name":"Jerry E. Carr","orcid":"0000-0002-8705-0080","position":6,"is_corresponding":false},{"id":1007555,"name":"Christopher Hulme","orcid":"0000-0001-6602-9613","position":7,"is_corresponding":false},{"id":1623551,"name":"Paco Cardenas","orcid":null,"position":8,"is_corresponding":false},{"id":407436,"name":"Todd W. Vanderah","orcid":"0000-0003-0406-4354","position":9,"is_corresponding":false},{"id":413257,"name":"John M. Streicher","orcid":"0000-0002-4173-7362","position":10,"is_corresponding":false},{"id":1623552,"name":"Christopher Cartmell","orcid":"0000-0002-8722-9187","position":11,"is_corresponding":false},{"id":1164498,"name":"Caleb Seekins","orcid":"0009-0008-1110-7125","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Barettin, a Nonopioid, Nonhallucinogenic Marine Natural Product with Antihyperalgesic Properties Mediated by 5HT2A Inverse Agonism","abstract":"Despite increasing interest, there remain limited treatments for chronic pain, with opioids continuing to be one of the top prescribed medications. Marine natural products present a wealth of untapped potential for new treatments for chronic pain. In this study, we investigated the analgesic effects of the sea sponge ligand barettin in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN). Barettin exhibited efficacious antihyperalgesic activity in male mice with no efficacy shown in females. Through the use of a PRESTO-Tango assay, we found that barettin acts as an inverse agonist at the 5HT2A receptor while also presenting no activity at the μ-opioid receptor. Head twitch experiments confirmed no hallucinogenic activity, suggesting that barettin may be a promising nonopioid, nonhallucinogenic, marine-derived therapeutic agent for the treatment of chronic pain.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41914263","pmcid":"PMC13122638","openalex_id":"https://openalex.org/W7144338053","authors":[],"funders":[{"funder_name":"H2020 Environment","grant_id":"679849","title":null},{"funder_name":"Arizona Biomedical Research Commission","grant_id":"","title":null}],"total_grants":2,"fwci":4.631,"citation_percentile":0.93511989,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.6c00169?ref=article_openPDF","host_type":"journal"},{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.6c00169?ref=article_openPDF","host_type":"publisher"},{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.6c00169","host_type":"publisher"},{"url":"https://doi.org/10.1021/acs.jnatprod.6c00169","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41914263","host_type":"repository"},{"url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-588948","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13122638/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC13122638","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC13122638?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Marine Sponges and Natural Products","Seaweed-derived Bioactive Compounds","Marine Toxins and Detection Methods","Animals","Mice","Male","Biological Products","Analgesics","Hyperalgesia","Molecular Structure","Female","Chronic Pain","Porifera","Receptors, Opioid, mu"],"mesh_terms":["Analgesics","Animals","Biological Products","Female","Hyperalgesia","Male","Porifera","Molecular Structure","Receptors, Opioid, mu","Receptor, Serotonin, 5-HT2A","Mice","Serotonin 5-HT2 Receptor Agonists","Chronic Pain"],"keywords":["Agonism","Natural product","Product (mathematics)","Structure–activity relationship","Natural (archaeology)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T17:03:22.912401Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}