{"doi":"10.1021/acs.jnatprod.5c00876","title":"The Role of Nucleotide Sequencing in Natural Product Drug Discovery","abstract":"For millennia, humans have drawn upon natural sources for medicinal remedies. However, the discovery process was often a serendipitous endeavor, and the true biosynthetic potential of the planet's biodiversity remained largely hidden. The advent of nucleotide sequencing offered a pivotal shift, providing tools to decipher the cryptic codes within biosynthetic machinery. In this Perspective, I describe the arc of the sequencing era, from its foundational impact to the current landscape of sophisticated bioinformatic tools. Furthermore, I will address the international legal frameworks being implemented to protect the very biodiversity upon which the field of natural product discovery relies.","journal":"Journal of Natural Products","year":2025,"id":534833,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9413,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":994247,"name":"Samantha C. Waterworth","orcid":"0000-0001-6436-0142","position":0,"is_corresponding":true}],"reference_count":299,"raw_metadata":null,"created_at":"2026-07-19T02:51:52.019261Z","pmid":"40998407","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}