{"doi":"10.1021/acs.jnatprod.2c01003","title":"Isolation and Characterization of Anti-Mycobacterial Natural Products from a <i>Petrosia</i> sp. Marine Sponge","abstract":"High Resolution Image Download MS PowerPoint Slide Tuberculosis (TB) is a dreadful infectious disease and a leading cause of mortality and morbidity worldwide, second in 2020 only to severe acute respiratory syndrome 2 (SARS-Cov-2). With limited therapeutic options available and a rise in multidrug-resistant tuberculosis cases, it is critical to develop antibiotic drugs that display novel mechanisms of action. Bioactivity-guided fractionation employing an Alamar blue assay for Mycobacterium tuberculosis strain H37Rv led to the isolation of duryne ( 13 ) from a marine sponge Petrosia sp. sampled in the Solomon Islands. Additionally, five new strongylophorine meroditerpene analogues ( 1 – 5 ) along with six known strongylophorines ( 6 – 12 ) were isolated from the bioactive fraction and characterized using MS and NMR spectroscopy, although only 13 exhibited antitubercular activity.","journal":"Journal of Natural Products","year":2023,"id":340791,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1049256,"name":"Riya Bhanushali","orcid":null,"position":1,"is_corresponding":false},{"id":1075831,"name":"Yifan Liang","orcid":"0009-0003-9205-3678","position":2,"is_corresponding":false},{"id":1075832,"name":"Marisa R. Cepeda","orcid":"0000-0001-7212-5679","position":3,"is_corresponding":false},{"id":1076308,"name":"Adi Kula Niradininoco","orcid":null,"position":4,"is_corresponding":false},{"id":456400,"name":"Katy Soapi","orcid":"0000-0001-9856-6077","position":5,"is_corresponding":false},{"id":1076309,"name":"Baojie Wan","orcid":null,"position":6,"is_corresponding":false},{"id":1075833,"name":"Mallique Qader","orcid":"0000-0003-0817-3435","position":7,"is_corresponding":false},{"id":352862,"name":"Scott G. Franzblau","orcid":"0000-0002-8698-0243","position":8,"is_corresponding":false},{"id":337555,"name":"Julia Kubanek","orcid":"0000-0003-4482-1831","position":9,"is_corresponding":false},{"id":382899,"name":"Bhuwan K. Chhetri","orcid":"0000-0002-4199-2718","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T01:10:58.548803Z","pmid":"36881908","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}