{"doi":"10.1021/acs.jnatprod.2c00752","title":"Tigliane-Type Diterpene Esters from the Fruits of <i>Shirakiopsis indica</i> and Their Anti-HIV Activity","abstract":null,"journal":"Journal of Natural Products","year":2022,"id":674141,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1761365,"name":"Sakura Takahashi","orcid":null,"position":1,"is_corresponding":false},{"id":203086,"name":"Yuki Yoshino","orcid":null,"position":2,"is_corresponding":false},{"id":1761366,"name":"Megumi Nakatani","orcid":null,"position":3,"is_corresponding":false},{"id":1761367,"name":"Fakhruddin Ali Ahmed","orcid":null,"position":4,"is_corresponding":false},{"id":1761368,"name":"Gazi Mosharof Hossain","orcid":null,"position":5,"is_corresponding":false},{"id":544636,"name":"Chin-Ho Chen","orcid":null,"position":6,"is_corresponding":false},{"id":244476,"name":"Kuo‐Hsiung Lee","orcid":"0000-0002-6562-0070","position":7,"is_corresponding":false},{"id":591994,"name":"Yoshiki Kashiwada","orcid":"0000-0002-5429-3211","position":8,"is_corresponding":false},{"id":1761364,"name":"Naonobu Tanaka","orcid":"0000-0002-9281-7098","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Tigliane-Type Diterpene Esters from the Fruits of <i>Shirakiopsis indica</i> and Their Anti-HIV Activity","abstract":"Four new diterpene esters, shirakindicans A-D (<b>1</b>-<b>4</b>), along with eight related known diterpene esters (<b>5</b>-<b>12</b>), were isolated from the fruits of the Bangladeshi medicinal plant <i>Shirakiopsis indica</i>. The structures of <b>1</b>-<b>4</b> were elucidated by spectroscopic data analysis and electronic circular dichroism (ECD) calculations. Shirakindican A (<b>1</b>) was assigned as a tigliane-type diterpene ester possessing an unusual 6β-hydroxy-1,7-dien-3-one structure, while shirakindican B (<b>2</b>) exhibits a tiglia-1,5-dien-3,7-dione structure. The anti-HIV activities of the isolated diterpene esters were evaluated and showed significant activities for sapintoxins A (<b>5</b>) and D (<b>11</b>), with EC<sub>50</sub> values of 0.0074 and 0.044 μM, respectively, and TI values of 1 100 and 5 290. Sapatoxin A (<b>12</b>) also exhibited anti-HIV activity with an EC<sub>50</sub> value of 0.13 μM and a TI value of 161.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36378070","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Japan Society for the Promotion of Science","grant_id":"JP20K07113","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.2c00752","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Cell Line","Humans","HIV","Euphorbiaceae","Fruit","Phorbol Esters","Anti-HIV Agents","Molecular Structure"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T15:44:48.494077Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}