{"doi":"10.1021/acs.jnatprod.2c00684","title":"Highly <i>N</i>-Methylated Peptides from the Antarctic Sponge <i>Inflatella coelosphaeroides</i> Are Active against <i>Plasmodium falciparum</i>","abstract":"Malaria, caused by the parasite Plasmodium falciparum, continues to threaten much of the world’s population, and there is a pressing need for expanding treatment options. Natural products have been a vital source of such drugs, and here we report seven new highly N-methylated linear peptides, friomaramide B (2) and shagamides A–F (3–8) from the marine sponge Inflatella coelosphaeroides, collected in Antarctic waters, which demonstrate activity against three strains of blood-stage P. falciparum. The planar structures of these metabolites were solved by interpreting NMR data, as well as HRESIMS/MS fragmentation patterns, while Marfey’s analysis was used to establish the configurations of the amino acids. Reisolation of the previously reported compound friomaramide A (1) allowed us to revise its structure. The panel of isolated compounds allowed establishing structure/activity relationships and provided information for future structure optimization for this class of P. falciparum inhibitory metabolites.","journal":"Journal of Natural Products","year":2022,"id":273219,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9505,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":429394,"name":"Debora Casandra","orcid":null,"position":1,"is_corresponding":false},{"id":272888,"name":"James R. Rocca","orcid":null,"position":2,"is_corresponding":false},{"id":398225,"name":"John H. Adams","orcid":"0000-0003-3707-7979","position":3,"is_corresponding":false},{"id":398228,"name":"Bill J. Baker","orcid":"0000-0003-3033-5779","position":4,"is_corresponding":false},{"id":940247,"name":"Joe Bracegirdle","orcid":"0000-0001-7725-3477","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:27:52.048702Z","pmid":"36178104","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}