{"doi":"10.1021/acs.jnatprod.1c00192","title":"Himalaquinones A–G, Angucyclinone-Derived Metabolites Produced by the Himalayan Isolate <i>Streptomyces</i> sp. PU-MM59","abstract":"sp. PU-MM59. The chemical structures of the new compounds were identified based on cumulative analyses of HRESIMS and NMR spectra. Himalaquinones A-F were determined to be unique anthraquinones that contained unusual C-4a 3-methylbut-3-enoic acid aromatic substitutions, while himalaquinone G was identified as a new 5,6-dihydrodiol-bearing angucyclinone. Comparative bioactivity assessment (antimicrobial, cancer cell line cytotoxicity, impact on 4E-BP1 phosphorylation, and effect on axolotl embryo tail regeneration) revealed cytotoxic landomycin and saquayamycin analogues to inhibit 4E-BP1p and inhibit regeneration. In contrast, himalaquinone G, while also cytotoxic and a regeneration inhibitor, did not affect 4E-BP1p status at the doses tested. As such, this work implicates a unique mechanism for himalaquinone G and possibly other 5,6-dihydrodiol-bearing angucyclinones.","journal":"Journal of Natural Products","year":2021,"id":189223,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9485,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":751310,"name":"Mohsin Tassawar Cheema","orcid":"0000-0002-4399-811X","position":1,"is_corresponding":false},{"id":751311,"name":"Larissa V. Ponomareva","orcid":"0000-0003-2182-8774","position":2,"is_corresponding":false},{"id":751312,"name":"Qing Ye","orcid":"0000-0001-6874-5146","position":3,"is_corresponding":false},{"id":751313,"name":"Tao Liu","orcid":"0000-0002-7076-1273","position":4,"is_corresponding":false},{"id":751314,"name":"Imran Sajid","orcid":"0000-0002-4781-1455","position":5,"is_corresponding":false},{"id":376910,"name":"Jürgen Rohr","orcid":"0000-0001-6447-5951","position":6,"is_corresponding":false},{"id":271902,"name":"Qing‐Bai She","orcid":"0000-0002-7207-0599","position":7,"is_corresponding":false},{"id":457703,"name":"S. Randal Voss","orcid":"0000-0002-8332-3176","position":8,"is_corresponding":false},{"id":689081,"name":"Jon S. Thorson","orcid":"0000-0002-7148-0721","position":9,"is_corresponding":false},{"id":689082,"name":"Khaled A. Shaaban","orcid":"0000-0001-7638-4942","position":10,"is_corresponding":false},{"id":751309,"name":"Yongyong Zhang","orcid":"0000-0002-2451-2428","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-18T23:49:14.547082Z","pmid":"34170698","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}