{"doi":"10.1021/acs.jmedchem.0c02178","title":"Agonist Lock Touched and Untouched Retinoic Acid Receptor-Related Orphan Receptor-γt (RORγt) Inverse Agonists: Classification Based on the Molecular Mechanisms of Action","abstract":null,"journal":"Journal of Medicinal Chemistry","year":2021,"id":13844,"datarank":0.99493574285795,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.49510506633166934,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.49510506633166934,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":22,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":111898,"name":"Qiong Xie","orcid":"0000-0002-1801-4561","position":1,"is_corresponding":false},{"id":111899,"name":"Yongjun Dang","orcid":"0000-0001-7237-1132","position":2,"is_corresponding":false},{"id":73841,"name":"Yonghui Wang","orcid":"0000-0002-0262-2431","position":3,"is_corresponding":false},{"id":111897,"name":"Nannan Sun","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34264059","pmcid":null,"openalex_id":"https://openalex.org/W3180971434","authors":[],"funders":[{"funder_name":"Natural Science Foundation of Shanghai","grant_id":"19ZR1436700","title":null},{"funder_name":"Ministry of Science and Technology of the People's Republic of China","grant_id":"2018ZX09711002-003-014","title":null},{"funder_name":"China Postdoctoral Science Foundation","grant_id":"2019M651383","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81573276","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81874287","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81973163","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82003577","title":null},{"funder_name":"Shanghai Bio-pharmaceutical Science and Technology Supporting Plan","grant_id":"17431902100","title":null},{"funder_name":"Shanghai Bio-pharmaceutical Science and Technology Supporting Plan","grant_id":"19431900100","title":null}],"total_grants":9,"fwci":1.8001,"citation_percentile":0.85283769,"influential_citations":0,"citation_trend":[{"year":2021,"count":5},{"year":2022,"count":4},{"year":2023,"count":10},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"green","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://doi.org/10.7270/q2jm2ftp","host_type":"repository"},{"url":"https://doi.org/10.7270/q2jm2ftp","host_type":"repository"},{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02178","host_type":"publisher"},{"url":"https://doi.org/10.1021/acs.jmedchem.0c02178","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34264059","host_type":"repository"}],"fields_of_study":["Psoriasis: Treatment and Pathogenesis","IL-33, ST2, and ILC Pathways","Asthma and respiratory diseases","Medicine","Chemistry","Dose-Response Relationship, Drug","Humans","Molecular Structure","Nuclear Receptor Subfamily 1, Group F, Member 3","Organic Chemicals","Structure-Activity Relationship"],"mesh_terms":["Dose-Response Relationship, Drug","Humans","Organic Chemicals","Structure-Activity Relationship","Molecular Structure","Nuclear Receptor Subfamily 1, Group F, Member 3"],"keywords":["Inverse agonist","RAR-related orphan receptor gamma","Orphan receptor","Coactivator","Agonist","Chemistry","Retinoic acid receptor","Retinoic acid","Nuclear receptor","Receptor","Pharmacology","Cell biology","Transcription factor","Biochemistry","Biology","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-05-31T19:00:51.859611Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}