{"doi":"10.1021/acs.jafc.9b07080","title":"Artepillin C, a Key Component of Brazilian Propolis, Induces Thermogenesis in Inguinal White Adipose Tissue of Mice through a Creatine-Metabolism-Related Thermogenic Pathway","abstract":null,"journal":"Journal of Agricultural and Food Chemistry","year":2020,"id":678179,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1771928,"name":"Takuma Hydo","orcid":null,"position":1,"is_corresponding":false},{"id":1771931,"name":"Hiroki Aoyama","orcid":null,"position":2,"is_corresponding":false},{"id":1771933,"name":"Ryo Miyata","orcid":null,"position":3,"is_corresponding":false},{"id":1771934,"name":"Shigenori Kumazawa","orcid":"0000-0001-9687-9619","position":4,"is_corresponding":false},{"id":1771935,"name":"Takanori Tsuda","orcid":"0000-0002-7761-8824","position":5,"is_corresponding":false},{"id":1551017,"name":"Sho Nishikawa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Artepillin C, a Key Component of Brazilian Propolis, Induces Thermogenesis in Inguinal White Adipose Tissue of Mice through a Creatine-Metabolism-Related Thermogenic Pathway","abstract":"Induction of beige adipocytes in white adipose tissue (WAT) is a potential therapeutic target for the treatment of obesity because beige adipocytes release excess energy via uncoupling-protein-1-associated thermogenesis. In this study, we investigated how artepillin C (ArtC) promotes thermogenesis in vivo . We demonstrated that 28 day administration of ArtC (10 mg/kg of body weight) to mice significantly induced thermogenesis in beige adipocytes in inguinal WAT (iWAT) and suppressed reductions in core body temperature induced by cold exposure at 4 °C. Moreover, ArtC-induced thermogenesis in iWAT was significantly inhibited by treatment with a creatine metabolism inhibitor, and ArtC significantly upregulated the expression of creatine-metabolism-related enzymes in the thermogenic pathway. These results indicate that ArtC induces thermogenesis in beige adipocytes in iWAT, and the observed ArtC-induced thermogenesis is associated with the creatine-metabolism-related thermogenic pathway, which is characteristically observed in beige adipocytes.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31914311","pmcid":null,"openalex_id":"https://openalex.org/W2999785765","authors":[],"funders":[{"funder_name":"Grants-in-Aid for Scientific Research from the Japan Society for Promotion of Science","grant_id":"17K07804","title":null},{"funder_name":"Grants-in-Aid for Scientific Research from the Japan Society for Promotion of Science","grant_id":"18H02157","title":null},{"funder_name":"Grants-in-Aid for Scientific Research from the Japan Society for Promotion of Science","grant_id":"18K14428","title":null},{"funder_name":"Grants-in-Aid for Scientific Research from the Japan Society for Promotion of Science","grant_id":"18KK0165","title":null}],"total_grants":4,"fwci":1.017,"citation_percentile":0.74147058,"influential_citations":1,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":4},{"year":2022,"count":1},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":5}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.9b07080","host_type":"publisher"},{"url":"https://doi.org/10.1021/acs.jafc.9b07080","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31914311","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32052959","host_type":"repository"}],"fields_of_study":["Adipose Tissue and Metabolism","Exercise and Physiological Responses","Muscle metabolism and nutrition","Medicine","Chemistry","Environmental Science"],"mesh_terms":["Adipocytes, Beige","Animals","Body Temperature","Brazil","Creatine","Humans","Male","Mice, Inbred C57BL","Obesity","Phenylpropionates","Propolis","Thermogenesis","Mice","Adipose Tissue, White"],"keywords":["Thermogenesis","White adipose tissue","Adipose tissue","Endocrinology","Internal medicine","Creatine","Metabolism","Chemistry","Thermogenin","Biology","Medicine","Propolis","Beige Adipocyte","Artepillin C","Creatine Metabolism"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T05:02:25.813687Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}