{"doi":"10.1021/acs.est.1c02549","title":"Correlates of Persistent Endocrine-Disrupting Chemical Mixtures among Reproductive-Aged Black Women","abstract":"Black women are exposed to multiple endocrine-disrupting chemicals (EDCs), but few studies have examined their profiles of exposure to EDC mixtures. We identified biomarker profiles and correlates of exposure to EDC mixtures in a cross-sectional analysis of data from a prospective cohort study of 749 Black women aged 23–35 years. We quantified plasma concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), organochlorine pesticides (OCPs), and per- and polyfluoroalkyl substances (PFAS) in nonfasting samples collected at baseline. Demographic, behavioral, dietary, and reproductive covariates were also collected at baseline. We used k-means clustering and principal component analysis (PCA) to describe concentration profiles of EDC mixtures (17 PCBs, 6 PBDEs, 4 OCPs, 6 PFAS), followed by multinomial logistic and multivariable linear regression to estimate mean differences in PCA scores (β) and odds ratios (ORs) of cluster membership with their respective 95% confidence intervals (CIs). Older age (per 1 year increase: β = 0.47, CI = 0.39, 0.54; OR = 1.27, CI = 1.20, 1.35), lower body mass index (per 1 kg/m2 increase: β = −0.14, CI = −0.17, −0.12; OR = 0.91, CI = 0.89, 0.94), and current smoking (≥10 cigarettes/day vs never smokers: β = 1.37, CI = 0.20, 2.55; OR = 2.63, CI = 1.07, 6.50) were associated with profiles characterized by higher concentrations of all EDCs. Other behaviors and traits, including dietary factors and years since last birth, were also associated with EDC mixtures.","journal":"Environmental Science & Technology","year":2021,"id":181523,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9404,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":329832,"name":"Lauren A. Wise","orcid":"0000-0003-2138-3752","position":1,"is_corresponding":false},{"id":371912,"name":"Amelia K. Wesselink","orcid":"0000-0002-3929-4451","position":2,"is_corresponding":false},{"id":732466,"name":"Payton De La Cruz","orcid":"0000-0001-7483-4196","position":3,"is_corresponding":false},{"id":299778,"name":"Traci N. Bethea","orcid":"0000-0003-3205-2078","position":4,"is_corresponding":false},{"id":280504,"name":"Jennifer Weuve","orcid":"0000-0003-0922-0256","position":5,"is_corresponding":false},{"id":467212,"name":"Victoria Fruh","orcid":"0000-0003-1048-7230","position":6,"is_corresponding":false},{"id":691635,"name":"Julianne Cook Botelho","orcid":null,"position":7,"is_corresponding":false},{"id":354327,"name":"Andreas Sjödin","orcid":"0000-0002-0997-5758","position":8,"is_corresponding":false},{"id":241824,"name":"Antonia M. Calafat","orcid":"0000-0002-9796-7482","position":9,"is_corresponding":false},{"id":294195,"name":"Donna D. Baird","orcid":"0000-0002-5544-2653","position":10,"is_corresponding":false},{"id":254527,"name":"Birgit Claus Henn","orcid":"0000-0001-7118-4327","position":11,"is_corresponding":false},{"id":732465,"name":"Samantha Schildroth","orcid":"0000-0002-7845-3566","position":0,"is_corresponding":true}],"reference_count":110,"raw_metadata":null,"created_at":"2026-07-18T23:48:05.146883Z","pmid":"34591461","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}