{"doi":"10.1021/acs.cgd.0c00107","title":"Synthesis, Characterization, and Antimicrobial Investigation of a Novel Chlorhexidine Cyclamate Complex","abstract":"The synthesis, crystal structure, and antimicrobial efficacy are reported for a novel material comprising a 1:2 ratio of chlorhexidine (CHX) to N-cyclohexylsulfamate (i.e., artificial sweetener known as cyclamate). The chemical structure is unambiguously identified by incorporating a combination of single-crystal X-ray diffraction (SC-XRD), electrospray ionization mass spectrometry (ESI-MS), 1H nuclear magnetic resonance (NMR) spectroscopy, correlation spectroscopy (COSY), and attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR). The new material: (1) is among only several reported structures identified to date incorporating the vital chlorhexidine antimicrobial drug; (2) exhibits broad spectrum antimicrobial activity at concentrations less than 15 μg/mL; and (3) provides a unique delivery method for the essential active pharmaceutical ingredient. Furthermore, substitution of inactive gluconate with bioactive cyclamate counterion potentially provides the additional benefit of improving the taste profile of chlorhexidine.","journal":"Crystal Growth & Design","year":2020,"id":89964,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":370380,"name":"Primit Desai","orcid":null,"position":1,"is_corresponding":false},{"id":454343,"name":"Zhigang Hao","orcid":"0000-0002-3487-7682","position":2,"is_corresponding":false},{"id":454344,"name":"Chi‐Yuan Cheng","orcid":"0000-0001-7117-3097","position":3,"is_corresponding":false},{"id":369271,"name":"Gaurav Verma","orcid":"0000-0002-1894-1103","position":4,"is_corresponding":false},{"id":369272,"name":"Łukasz Wojtas","orcid":"0000-0003-0545-0302","position":5,"is_corresponding":false},{"id":370381,"name":"Tatiana V. Brinzari","orcid":null,"position":6,"is_corresponding":false},{"id":14332,"name":"Jeffrey M. Boyd","orcid":"0000-0001-7721-3926","position":7,"is_corresponding":false},{"id":369273,"name":"Shengqian Ma","orcid":"0000-0002-1897-7069","position":8,"is_corresponding":false},{"id":369274,"name":"Tewodros Asefa","orcid":"0000-0001-8634-5437","position":9,"is_corresponding":false},{"id":369275,"name":"Long Pan","orcid":"0000-0003-0438-4040","position":10,"is_corresponding":false},{"id":369269,"name":"Viktor Dubovoy","orcid":"0000-0001-7661-0823","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T22:02:48.683291Z","pmid":"34054352","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}