{"doi":"10.1021/acs.biomac.4c00904","title":"Composite Hyaluronic Acid Gas-Entrapping Materials to Promote Wound Healing","abstract":"Tissue repair is often impaired in pathological states, highlighting the need for innovative wound-healing technologies. This study introduces composite hyaluronic acid gas-entrapping materials (GEMs) delivering carbon monoxide (CO) to promote wound healing in pigs. These composite materials facilitate burst release followed by sustained release of CO over 48 h. In a porcine full-thickness wound model, CO-GEMs significantly accelerated wound closure compared to the standard-of-care dressing (Tegaderm). Wound area closure with CO-GEMs was 68.6% vs 56.8% on day 14, 41.0% vs 25.1% on day 28, and 26.9% vs 11.8% on day 42, effectively reducing healing time by 14 days. Histological analysis revealed increased epithelialization and neovascularization with reduced inflammation. These findings demonstrate the potential of CO-GEMs as a topical therapeutic to enhance tissue repair in clinically relevant models, supporting further testing for wound-healing applications.","journal":"Biomacromolecules","year":2025,"id":517634,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1310290,"name":"Emily Petersen","orcid":"0000-0001-7830-597X","position":1,"is_corresponding":false},{"id":1384624,"name":"Eyas Alzayadneh","orcid":null,"position":2,"is_corresponding":false},{"id":1384625,"name":"Ryan Courtney","orcid":null,"position":3,"is_corresponding":false},{"id":447545,"name":"Marc J. Brouillette","orcid":"0000-0001-7206-8627","position":4,"is_corresponding":false},{"id":288882,"name":"Qi Wang","orcid":"0000-0002-0854-6505","position":5,"is_corresponding":false},{"id":1383977,"name":"Maxwell Y. Sakyi","orcid":"0000-0002-8873-4484","position":6,"is_corresponding":false},{"id":1384626,"name":"Nicole A. DeVries Watson","orcid":null,"position":7,"is_corresponding":false},{"id":992870,"name":"Dominic J. L. Rivas","orcid":null,"position":8,"is_corresponding":false},{"id":652441,"name":"Jianling Bi","orcid":null,"position":9,"is_corresponding":false},{"id":1384627,"name":"L. E. Culver","orcid":null,"position":10,"is_corresponding":false},{"id":1384628,"name":"Kyle R. Balk","orcid":null,"position":11,"is_corresponding":false},{"id":1383978,"name":"César P. Reis","orcid":"0000-0001-8481-8587","position":12,"is_corresponding":false},{"id":1239974,"name":"Slyn Uaroon","orcid":null,"position":13,"is_corresponding":false},{"id":1384629,"name":"Kaitlyn A. McClintic","orcid":null,"position":14,"is_corresponding":false},{"id":1239479,"name":"Samual Hatfield","orcid":"0000-0003-0073-7021","position":15,"is_corresponding":false},{"id":753282,"name":"Kristan S. Worthington","orcid":"0000-0002-0693-0685","position":16,"is_corresponding":false},{"id":827609,"name":"Edward A. Sander","orcid":"0000-0002-7917-4083","position":17,"is_corresponding":false},{"id":267362,"name":"Giovanni Traverso","orcid":"0000-0001-7851-4077","position":18,"is_corresponding":false},{"id":402414,"name":"Leo E. Otterbein","orcid":"0000-0002-7900-0825","position":19,"is_corresponding":false},{"id":393431,"name":"Jessica E. Goetz","orcid":"0000-0002-7197-5978","position":20,"is_corresponding":false},{"id":925866,"name":"Douglas C. Fredericks","orcid":"0000-0003-3275-9508","position":21,"is_corresponding":false},{"id":371631,"name":"James D. Byrne","orcid":"0000-0002-6436-2866","position":22,"is_corresponding":false},{"id":1064407,"name":"Emily Witt","orcid":null,"position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:48:59.410472Z","pmid":"39746190","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}