{"doi":"10.1021/acs.biochem.8b01194","title":"Phospholipid Membrane Fluidity Alters Ligand Binding Activity of a G Protein-Coupled Receptor by Shifting the Conformational Equilibrium","abstract":null,"journal":"Biochemistry","year":2019,"id":642473,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":941859,"name":"Satoru Nagatoishi","orcid":"0000-0002-0794-3963","position":1,"is_corresponding":false},{"id":724178,"name":"Daisuke Kuroda","orcid":"0000-0003-2390-4785","position":2,"is_corresponding":false},{"id":1671152,"name":"Nanao Suzuki","orcid":null,"position":3,"is_corresponding":false},{"id":1484054,"name":"Takeshi Murata","orcid":"0000-0002-5748-4670","position":4,"is_corresponding":false},{"id":724179,"name":"Kouhei Tsumoto","orcid":"0000-0001-7643-5164","position":5,"is_corresponding":false},{"id":1671151,"name":"Kouhei Yoshida","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Phospholipid Membrane Fluidity Alters Ligand Binding Activity of a G Protein-Coupled Receptor by Shifting the Conformational Equilibrium","abstract":"The affinity of a ligand for a receptor on the cell surface will be influenced by the membrane composition. Herein, we evaluated the effects of differences in membrane fluidity, controlled by phospholipid composition, on the ligand binding activity of the G protein-coupled receptor human serotonin 2B. Using Nanodisc technology to control membrane properties, we performed biophysical analysis and employed molecular dynamics simulations to demonstrate that increased membrane fluidity shifted the equilibrium toward an active form of the receptor. Our quantitative study will enable development of more realistic in vitro drug discovery assays involving membrane-bound proteins such as G protein-coupled receptors.","is_dataset_classified":null,"base_score":3.713572066704308,"endowment":3.713572066704308,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30618239","pmcid":null,"openalex_id":"https://openalex.org/W2908711406","authors":[],"funders":[{"funder_name":"Japan Agency for Medical Research and Development","grant_id":"JP18am0101094","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"18H05425","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"16H02420","title":null}],"total_grants":3,"fwci":2.4857,"citation_percentile":0.89962403,"influential_citations":0,"citation_trend":[{"year":2019,"count":2},{"year":2020,"count":13},{"year":2021,"count":5},{"year":2022,"count":10},{"year":2023,"count":4},{"year":2024,"count":2},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.8b01194","host_type":"publisher"},{"url":"https://doi.org/10.1021/acs.biochem.8b01194","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30618239","host_type":"repository"}],"fields_of_study":["Receptor Mechanisms and Signaling","Lipid Membrane Structure and Behavior","Ion channel regulation and function","Humans","Membrane Fluidity","Phospholipids","Protein Conformation","Receptor, Serotonin, 5-HT2B","Serotonin"],"mesh_terms":["Humans","Membrane Fluidity","Phospholipids","Protein Conformation","Serotonin","Receptor, Serotonin, 5-HT2B"],"keywords":["Nanodisc","Membrane fluidity","Biophysics","Phospholipid","Chemistry","Ligand (biochemistry)","Membrane","Receptor","Membrane protein","Lipid bilayer","G protein-coupled receptor","Cell surface receptor","Biochemistry","Cell membrane","Biology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T22:53:17.707455Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}