{"doi":"10.1017/ice.2021.336","title":"Real-world impact of vaccination on coronavirus disease 2019 (COVID-19) incidence in healthcare personnel at an academic medical center","abstract":"Abstract Objective: Coronavirus disease 2019 (COVID-19) vaccination effectiveness in healthcare personnel (HCP) has been established. However, questions remain regarding its performance in high-risk healthcare occupations and work locations. We describe the effect of a COVID-19 HCP vaccination campaign on SARS-CoV-2 infection by timing of vaccination, job type, and work location. Methods: We conducted a retrospective review of COVID-19 vaccination acceptance, incidence of postvaccination COVID-19, hospitalization, and mortality among 16,156 faculty, students, and staff at a large academic medical center. Data were collected 8 weeks prior to the start of phase 1a vaccination of frontline employees and ended 11 weeks after campaign onset. Results: The COVID-19 incidence rate among HCP at our institution decreased from 3.2% during the 8 weeks prior to the start of vaccinations to 0.38% by 4 weeks after campaign initiation. COVID-19 risk was reduced among individuals who received a single vaccination (hazard ratio [HR], 0.52; 95% confidence interval [CI], 0.40–0.68; P < .0001) and was further reduced with 2 doses of vaccine (HR, 0.17; 95% CI, 0.09–0.32; P < .0001). By 2 weeks after the second dose, the observed case positivity rate was 0.04%. Among phase 1a HCP, we observed a lower risk of COVID-19 among physicians and a trend toward higher risk for respiratory therapists independent of vaccination status. Rates of infection were similar in a subgroup of nurses when examined by work location. Conclusions: Our findings show the real-world effectiveness of COVID-19 vaccination in HCP. Despite these encouraging results, unvaccinated HCP remain at an elevated risk of infection, highlighting the need for targeted outreach to combat vaccine hesitancy.","journal":"Infection Control and Hospital Epidemiology","year":2021,"id":199283,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.963,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":519221,"name":"Jason Y. Adams","orcid":"0000-0001-5623-8702","position":1,"is_corresponding":false},{"id":775300,"name":"Timothy E. Albertson","orcid":"0000-0001-5724-3300","position":2,"is_corresponding":false},{"id":650574,"name":"Maya Juarez","orcid":null,"position":3,"is_corresponding":false},{"id":609752,"name":"Sharon L. Myers","orcid":null,"position":4,"is_corresponding":false},{"id":245337,"name":"Ashish Atreja","orcid":"0000-0002-0628-4417","position":5,"is_corresponding":false},{"id":775301,"name":"Sumeet Batra","orcid":"0000-0003-2704-1980","position":6,"is_corresponding":false},{"id":290573,"name":"Elena Foster","orcid":null,"position":7,"is_corresponding":false},{"id":775721,"name":"Cy V. Huynh","orcid":null,"position":8,"is_corresponding":false},{"id":775722,"name":"Anna Y. Liu","orcid":null,"position":9,"is_corresponding":false},{"id":775302,"name":"David A. Lubarsky","orcid":"0000-0002-7809-5789","position":10,"is_corresponding":false},{"id":775303,"name":"Victoria Ngo","orcid":"0000-0001-9973-8379","position":11,"is_corresponding":false},{"id":485515,"name":"Christian E. Sandrock","orcid":null,"position":12,"is_corresponding":false},{"id":378690,"name":"Sandra L. Taylor","orcid":"0000-0001-7811-812X","position":13,"is_corresponding":false},{"id":775723,"name":"Ann M Tompkins","orcid":null,"position":14,"is_corresponding":false},{"id":104972,"name":"Stuart H. Cohen","orcid":null,"position":15,"is_corresponding":false},{"id":752117,"name":"Sarah Waldman","orcid":"0000-0002-9935-011X","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-18T23:50:36.595945Z","pmid":"34287111","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}