{"doi":"10.1017/ice.2020.1358","title":"Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence in healthcare personnel in northern California early in the coronavirus disease 2019 (COVID-19) pandemic","abstract":"OBJECTIVE: We assessed the magnitude of unidentified coronavirus disease 2019 (COVID-19) in our healthcare personnel (HCP) early in the COVID-19 pandemic, and we evaluated risk factors for infection to identify areas for improvement in infection control practice in a northern California academic medical center. METHODS: We reviewed anti-severe acute respiratory coronavirus virus 2 (SARS-CoV-2) receptor-binding domain (RBD) IgG serologic test results and self-reported risk factors for seropositivity among 10,449 asymptomatic HCP who underwent voluntary serology testing between April 20 and May 20, 2020. RESULTS: In total, 136 employees (1.3%) tested positive for SARS-CoV-2 IgG. This included 41 individuals (30.1%) who had previously tested positive for SARS-CoV-2 by nasopharyngeal reverse-transcription polymerase chain reaction (RT-PCR) between March 13 and April 16, 2020. In multivariable analysis, employees of Hispanic ethnicity (odds ratio [OR], 2.01; 95% confidence interval [CI], 1.22-3.46) and those working in environmental services, food services, or patient transport (OR, 4.81; 95% CI, 2.08-10.30) were at increased risk for seropositivity compared to other groups. Employees reporting a household contact with COVID-19 were also at higher risk for seropositivity (OR, 3.25; 95% CI, 1.47-6.44), but those with a work, exposure alone were not (OR, 1.27; 95% CI, 0.58-2.47). Importantly, one-third of seropositive individuals reported no prior symptoms, no suspected exposures, and no prior positive RT-PCR test. CONCLUSION: In this study, SARS-CoV-2 seropositivity among HCP early in the northern California epidemic appeared to be quite low and was more likely attributable to community rather than occupational exposure.","journal":"Infection Control and Hospital Epidemiology","year":2020,"id":77081,"datarank":1.4024320688786327,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.9457537032201193,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.9457537032201193,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":19,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8017,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":226825,"name":"Katharina Röltgen","orcid":"0000-0002-1582-1720","position":1,"is_corresponding":false},{"id":403286,"name":"Melissa Dymock","orcid":null,"position":2,"is_corresponding":false},{"id":403287,"name":"John Shepard","orcid":null,"position":3,"is_corresponding":false},{"id":401875,"name":"Andrew Martin","orcid":"0000-0002-9138-258X","position":4,"is_corresponding":false},{"id":226829,"name":"Catherine A. Hogan","orcid":"0000-0003-1977-253X","position":5,"is_corresponding":false},{"id":401876,"name":"Andra L. Blomkalns","orcid":"0000-0001-5760-6351","position":6,"is_corresponding":false},{"id":401877,"name":"Roshni Mathew","orcid":"0000-0003-2639-7053","position":7,"is_corresponding":false},{"id":231939,"name":"Julie Parsonnet","orcid":"0000-0001-7342-5366","position":8,"is_corresponding":false},{"id":226843,"name":"Benjamin A. Pinsky","orcid":"0000-0001-8751-4810","position":9,"is_corresponding":false},{"id":50477,"name":"Yvonne Maldonado","orcid":"0000-0002-5664-5583","position":10,"is_corresponding":false},{"id":226844,"name":"Scott D. Boyd","orcid":"0000-0003-0963-044X","position":11,"is_corresponding":false},{"id":403288,"name":"Sang-ick Chang","orcid":null,"position":12,"is_corresponding":false},{"id":401878,"name":"Marisa Holubar","orcid":"0000-0002-7585-1809","position":13,"is_corresponding":false},{"id":401874,"name":"Joelle I. Rosser","orcid":"0000-0001-7803-9333","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:48:50.085103Z","pmid":"33292895","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}