{"doi":"10.1017/ice.2014.22","title":"Triclosan-Coated Sutures Reduce the Risk of Surgical Site Infections: A Systematic Review and Meta-analysis","abstract":"<jats:sec id=\"S0899823X14000221_abs1\" sec-type=\"general\"><jats:title>OBJECTIVE</jats:title><jats:p>To analyze available evidence on the effectiveness of triclosan-coated sutures (TCSs) in reducing the risk of surgical site infection (SSI).</jats:p></jats:sec><jats:sec id=\"S0899823X14000221_abs2\" sec-type=\"general\"><jats:title>DESIGN</jats:title><jats:p>Systematic review and meta-analysis.</jats:p></jats:sec><jats:sec id=\"S0899823X14000221_abs3\" sec-type=\"methods\"><jats:title>METHODS</jats:title><jats:p>A systematic search of both randomized (RCTs) and nonrandomized (non-RCT) studies was performed on PubMed Medline, OVID, EMBASE, and SCOPUS, without restrictions in language and publication type. Random-effects models were utilized and pooled estimates were reported as the relative risk (RR) ratio with 95% confidence interval (CI). Tests for heterogeneity as well as meta-regression, subgroup, and sensitivity analyses were performed.</jats:p></jats:sec><jats:sec id=\"S0899823X14000221_abs4\" sec-type=\"results\"><jats:title>RESULTS</jats:title><jats:p>A total of 29 studies (22 RCTs, 7 non-RCTs) were included in the meta-analysis. The overall RR of acquiring an SSI was 0.65 (95% CI: 0.55–0.77; I<jats:sup>2</jats:sup>=42.4%, <jats:italic>P</jats:italic>=.01) in favor of TCS use. The pooled RR was particularly lower for the abdominal surgery group (RR: 0.56; 95% CI: 0.41–0.77) and was robust to sensitivity analysis. Meta-regression analysis revealed that study design, in part, may explain heterogeneity (<jats:italic>P</jats:italic>=.03). The pooled RR subgroup meta-analyses for randomized controlled trials (RCTs) and non-RCTs were 0.74 (95% CI: 0.61–0.89) and 0.53 (95% CI: 0.42–0.66), respectively, both of which favored the use of TCSs.</jats:p></jats:sec><jats:sec id=\"S0899823X14000221_abs5\" sec-type=\"conclusion\"><jats:title>CONCLUSION</jats:title><jats:p>The random-effects meta-analysis based on RCTs suggests that TCSs reduced the risk of SSI by 26% among patients undergoing surgery. This effect was particularly evident among those who underwent abdominal surgery.</jats:p><jats:p>Infect Control Hosp Epidemiol 2015;36(2): 1–11</jats:p></jats:sec>","journal":"Infection Control &amp; Hospital Epidemiology","year":2015,"id":44932,"datarank":2.07642348640708,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":1.530785562448122,"self_endowment_contribution":0.5456379239589579,"citer_contribution":1.530785562448122,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":37,"citers_with_citation_signal":32,"citers_with_endowment":32,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":210645,"name":"Nalini Singh","orcid":null,"position":1,"is_corresponding":false},{"id":210646,"name":"Aila Nica Bandong","orcid":null,"position":2,"is_corresponding":false},{"id":210647,"name":"Gilbert Madriaga","orcid":null,"position":3,"is_corresponding":false},{"id":210644,"name":"Anucha Apisarnthanarak","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25632999","pmcid":null,"openalex_id":"https://openalex.org/W2114346778","authors":[],"funders":[],"total_grants":0,"fwci":6.2064,"citation_percentile":0.96762878,"influential_citations":2,"citation_trend":[{"year":2015,"count":2},{"year":2016,"count":9},{"year":2017,"count":5},{"year":2018,"count":5},{"year":2019,"count":5},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.cambridge.org/core/terms","oa_locations":[{"url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0899823X14000221","host_type":"publisher"},{"url":"https://doi.org/10.1017/ice.2014.22","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25632999","host_type":"repository"}],"fields_of_study":["Surgical site infection prevention","Surgical Sutures and Adhesives","Reconstructive Surgery and Microvascular Techniques","Medicine","Abdomen","Anti-Infective Agents, Local","Humans","Randomized Controlled Trials as Topic","Surgical Wound Infection","Sutures","Triclosan"],"mesh_terms":["Abdomen","Anti-Infective Agents, Local","Humans","Surgical Wound Infection","Sutures","Triclosan","Randomized Controlled Trials as Topic"],"keywords":["Triclosan","Meta-analysis","Medicine","Surgical site infection","Anti-Infective Agents","MEDLINE","Surgery","Microbiology","Internal medicine","Chemistry","Antimicrobial","Biology","Pathology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-01T23:30:20.982290Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}