{"doi":"10.1017/cts.2024.485","title":"Practical application of good participatory practices for trials of emerging pathogens: Developing materials for use in ACTIV-3, -3b, and ACTIV-associated COVID-19 trials","abstract":"The emergence of the COVID-19 pandemic required an immediate global clinical research response. The ACTIV (Accelerating COVID-19 Therapeutic Interventions and Vaccines)-3 trials and the ACTIV-associated Outpatient Treatment with Anti-Coronavirus Immunoglobulin trial used Good Participatory Practices (GPP) to develop materials for study implementation from a global network perspective. GPP guidelines offer a framework for engaging stakeholders throughout the research process. This paper provides an overview of the materials developed and their applicability in various settings, reports results from a survey of study site personnel on the materials' usefulness, summarizes important lessons learned, and serves as a reference for networks eager to apply GPP. Survey results showed that flipbooks and overview videos were highly ranked. Stakeholder input was valuable in developing easily understandable participant-facing materials with culturally appropriate images. Materials should be available to submit with the initial protocol submissions to ethics committees, and in formats that accommodate a wide range of institutional resources, policies, and infection-control practices. This article emphasizes the importance of GPP, including stakeholder consultation, in developing materials that support clinical research and address language, cultural, and sociopolitical barriers during a pandemic. The findings will be used to optimize efforts and resource allocation for new and ongoing studies.","journal":"Journal of Clinical and Translational Science","year":2024,"id":481807,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9634,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":846587,"name":"Rubria Marines‐Price","orcid":"0000-0001-8361-8233","position":1,"is_corresponding":false},{"id":1322151,"name":"Olga Milman","orcid":null,"position":2,"is_corresponding":false},{"id":1322152,"name":"Danae Deal","orcid":null,"position":3,"is_corresponding":false},{"id":1322153,"name":"Jonathan Marchand","orcid":null,"position":4,"is_corresponding":false},{"id":1322154,"name":"Jessica Linton","orcid":null,"position":5,"is_corresponding":false},{"id":624877,"name":"Sue Meger","orcid":null,"position":6,"is_corresponding":false},{"id":1321733,"name":"John Rule","orcid":"0000-0001-7518-7744","position":7,"is_corresponding":false},{"id":341470,"name":"Thomas L Holland","orcid":"0000-0001-7745-9010","position":8,"is_corresponding":false},{"id":939144,"name":"Jonathan Kitonsa","orcid":"0000-0003-2467-4037","position":9,"is_corresponding":false},{"id":1067260,"name":"Yvette Delph","orcid":null,"position":10,"is_corresponding":false},{"id":1322155,"name":"for the INSIGHT OTAC, ACTIV-3 TICO, ACTIV-3 substudy VATICO, and ACTIV-3b TESICO Study Groups","orcid":null,"position":11,"is_corresponding":false},{"id":429838,"name":"Paola del Carmen Guerra-de-Blas","orcid":"0000-0003-3050-6865","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-19T02:07:10.067421Z","pmid":"39610837","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}