{"doi":"10.1017/cts.2023.704","title":"A role for adverse childhood experiences and depression in preeclampsia","abstract":"Abstract Introduction: Adverse childhood experiences (ACEs) are a measure of childhood adversity and are associated with life-long morbidity. The impacts of ACEs on peripartum health including preeclampsia, a common and dangerous hypertensive disorder of pregnancy, remain unclear, however. Therefore, we aimed to determine ACE association with peripartum psychiatric health and prevalence of preeclampsia using a case–control design. Methods: Clinical data were aggregated and validated using a large, intergenerational knowledgebase developed at our institution. Depression symptoms were measured by standard clinical screeners: the Patient Health Questionnaire-9 (PHQ-9) and the Edinburgh Postnatal Depression Scale (EPDS). ACEs were assessed via survey. Scores were compared between participants with ( N = 32) and without ( N = 46) prior preeclampsia. Results: Participants with ACE scores ≥4 had significantly greater odds of preeclampsia than those with scores ≤ 3 (adjusted odds ratio = 6.71, 95% confidence interval:1.13–40.00; p = 0.037). Subsequent speculative analyses revealed that increased odds of preeclampsia may be driven by increased childhood abuse and neglect dimensions of the ACE score. PHQ-9 scores (3.73 vs. 1.86, p = 0.03), EPDS scores (6.38 vs. 3.71, p = 0.01), and the incidence of depression (37.5% vs. 23.9%, p = 0.05) were significantly higher in participants with a history of preeclampsia versus controls. Conclusions: Childhood sets the stage for life-long health. Our findings suggest that ACEs may be a risk factor for preeclampsia and depression, uniting the developmental origins of psychiatric and obstetric risk.","journal":"Journal of Clinical and Translational Science","year":2024,"id":475288,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":257537,"name":"Serena B. Gumusoglu","orcid":"0000-0002-2098-388X","position":1,"is_corresponding":false},{"id":716793,"name":"Debra Brandt","orcid":"0000-0003-2616-3177","position":2,"is_corresponding":false},{"id":981209,"name":"Amy Stroud","orcid":null,"position":3,"is_corresponding":false},{"id":880718,"name":"Stephen K. Hunter","orcid":"0000-0002-4188-9569","position":4,"is_corresponding":false},{"id":683062,"name":"Julie Vignato","orcid":"0000-0003-4166-2599","position":5,"is_corresponding":false},{"id":716792,"name":"Virginia Nuckols","orcid":"0000-0001-5879-5991","position":6,"is_corresponding":false},{"id":406386,"name":"Gary L. Pierce","orcid":"0000-0001-7499-080X","position":7,"is_corresponding":false},{"id":257539,"name":"Mark K. Santillan","orcid":"0000-0002-3991-8017","position":8,"is_corresponding":false},{"id":257538,"name":"Donna A. Santillan","orcid":"0000-0002-6180-9714","position":9,"is_corresponding":false},{"id":924776,"name":"M Myers","orcid":"0000-0002-6749-918X","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T02:06:16.992586Z","pmid":"38384900","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}