{"doi":"10.1017/cts.2020.505","title":"Scale-up of the Accrual to Clinical Trials (ACT) network across the Clinical and Translational Science Award Consortium: a mixed-methods evaluation of the first 18 months","abstract":"INTRODUCTION: The Clinical and Translational Science Award (CTSA) Program is a Consortium of nearly 60 academic medical research centers across the USA and a natural network for evaluating the spread and uptake of translational research innovation across the Consortium. METHODS: Dissemination of the Accrual to Clinical Trials (ACT) Network, a federated clinical informatics data network for population-based cohort discovery, began January 2018 across the Consortium. Diffusion of innovation theory guided dissemination design and evaluation. Mixed-methods assessed the spread and uptake across the Consortium through July 1, 2019 (n = 48 CTSAs). Methods included prospective time activity tracking (Kaplan-Meier curves), and survey and qualitative interviews. RESULTS: Within 18 months, nearly 80% of CTSAs had joined the data network and two-thirds of CTSAs achieving technical readiness had initiated launch to local clinical investigators. Over 10,000 ACT Network queries are projected for 2019; and by 2020, nearly all CTSAs will have joined the network. Median time-from-technical-readiness-to-local-launch was 154 days (interquartile range: 87-225 days]. Quality improvement processes reduced time-to-launch by 35.2% (64 days, p = 0.0036). Lessons learned include: (1) conceptualize dissemination as two-stage adoption demonstrating value for both CTSA hub service providers and clinical investigators; (2) include institutional trial into dissemination strategies so CTSA hubs can refine internal workflows and gather local user feedback endorsement; (3) embrace designing-for-dissemination during technology development; and (4) sustain adaptive dissemination and customer relationship management to keep CTSA hubs and users engaged. CONCLUSIONS: Scale-up and spread of the ACT Network provides lessons learned for others disseminating innovation across the CTSA Consortium. The Network is primed for embedded implementation research.","journal":"Journal of Clinical and Translational Science","year":2020,"id":79556,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7844,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":413396,"name":"Lindsay Lennox","orcid":"0009-0007-8954-749X","position":1,"is_corresponding":false},{"id":414775,"name":"Elaina R Sendro","orcid":null,"position":2,"is_corresponding":false},{"id":413397,"name":"Anne Schuster","orcid":"0000-0002-0122-1150","position":3,"is_corresponding":false},{"id":96923,"name":"Harold Alan Pincus","orcid":null,"position":4,"is_corresponding":false},{"id":413398,"name":"Jennifer Humensky","orcid":"0000-0002-4965-166X","position":5,"is_corresponding":false},{"id":226228,"name":"Gary S. Firestein","orcid":"0000-0003-3495-960X","position":6,"is_corresponding":false},{"id":413399,"name":"Lee M. Nadler","orcid":"0000-0003-3031-6885","position":7,"is_corresponding":false},{"id":283029,"name":"Robert D. Toto","orcid":"0000-0001-9531-1749","position":8,"is_corresponding":false},{"id":413400,"name":"Steven E. Reís","orcid":"0000-0001-8023-0102","position":9,"is_corresponding":false},{"id":371421,"name":"Elaine H. Morrato","orcid":"0000-0001-6105-7826","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-18T21:50:57.971597Z","pmid":"33948228","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}