{"doi":"10.1017/ash.2024.420","title":"SARS-CoV-2 seropositivity among healthcare professionals in a rural state","abstract":"Objectives: We evaluated SARS-CoV-2 anti-nucleocapsid (anti-N) seroconversion and seroreversion rates, risk factors associated with SARS-CoV-2 seroconversion, and COVID-19 risk perceptions among academic healthcare center employees in a rural state. Methods: Among employees aged ≥18 years who completed a screening survey (n = 1,377), we invited all respondents reporting previous COVID-19 (n = 85; 82 accepted) and a random selection of respondents not reporting previous COVID-19 (n = 370; 220 accepted) to participate. Participants completed surveys and provided blood samples at 3-month intervals (T0, T3, T6, T9). We used logistic regression to identify risk factors for seropositivity at T0. Results: The cohort was primarily direct patient caregivers (205/302; 67.9%), white (278/302; 92.1%), and female (212/302; 70.2%). At T0, 86/302 (28.4%) participants were seropositive. Of the seronegative participants, 6/198 (3.0%), 6/183 (3.3%), and 14/180 (7.8%) had seroconverted at T3, T6, and T9, respectively. The overall seroreversion rate was 6.98% at T9. At T0, nursing staff (odds ratio [OR], 2.37; 95% confidence interval [CI], 1.08, 5.19) and being within six feet of a non-household member outside of work (OR, 2.91; 95% CI, 1.02, 8.33) had significantly higher odds of seropositivity. Vaccination (OR, 0.05; 95% CI, 0.02, 0.12) and face mask use (OR, 0.36; 95% CI, 0.17, 0.78) were protective. Conclusions: The seroconversion and seroreversion rates were low among participants. Public health and infection prevention measures implemented early in the COVID-19 pandemic - vaccination, face mask use, and social distancing - were associated with significantly lower odds of SARS-CoV-2 seropositivity among participants.","journal":"Antimicrobial Stewardship & Healthcare Epidemiology","year":2024,"id":505314,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8972,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1143042,"name":"Daniel Kang","orcid":"0000-0001-9860-9938","position":1,"is_corresponding":false},{"id":1356307,"name":"Allison Schuette","orcid":"0000-0003-0968-0340","position":2,"is_corresponding":false},{"id":788758,"name":"Melissa Ward","orcid":"0000-0002-1054-6475","position":3,"is_corresponding":false},{"id":611817,"name":"Matthew D. Krasowski","orcid":"0000-0003-0856-8402","position":4,"is_corresponding":false},{"id":636297,"name":"Aaron M. Scherer","orcid":"0000-0002-4134-9300","position":5,"is_corresponding":false},{"id":350367,"name":"Daniel J. Diekema","orcid":"0000-0003-1273-0724","position":6,"is_corresponding":false},{"id":540683,"name":"Joseph Cavanaugh","orcid":"0000-0002-0514-7664","position":7,"is_corresponding":false},{"id":788757,"name":"Loreen A. Herwaldt","orcid":"0000-0002-9530-6859","position":8,"is_corresponding":false},{"id":678849,"name":"Brianna Wright","orcid":"0000-0003-4284-1644","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:10:47.170978Z","pmid":"39465214","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}