{"doi":"10.1016/s0959-8049(97)00309-2","title":"Expression and function of Trk-C in favourable human neuroblastomas","abstract":null,"journal":"European Journal of Cancer","year":1997,"id":610925,"datarank":0.6646225198264971,"base_score":4.430816798843313,"endowment":4.430816798843313,"self_citation_contribution":0.6646225198264971,"citation_network_contribution":0.0,"self_endowment_contribution":0.6646225198264971,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":83,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1570947,"name":"X.-G Liu","orcid":null,"position":1,"is_corresponding":false},{"id":1570948,"name":"C.P Lee","orcid":null,"position":2,"is_corresponding":false},{"id":1559335,"name":"A Nakagawara","orcid":null,"position":3,"is_corresponding":false},{"id":1570949,"name":"N Ikegaki","orcid":null,"position":4,"is_corresponding":false},{"id":1570950,"name":"L.M McGregor","orcid":null,"position":5,"is_corresponding":false},{"id":1570951,"name":"S.B Baylin","orcid":null,"position":6,"is_corresponding":false},{"id":1559336,"name":"G.M Brodeur","orcid":null,"position":7,"is_corresponding":false},{"id":1570946,"name":"D.J Yamashiro","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Expression and function of Trk-C in favourable human neuroblastomas","abstract":"Human neuroblastomas express the neurotrophin receptors trk-A and trk-B. Favourable outcome is associated with expression of trk-A, while unfavourable, MYCN amplified tumours express trk-B. In this study we examined the expression of trk-C in primary neuroblastoma tumour-derived cell lines. We found by Northern blot analysis that trk-C mRNA is expressed in 14 of 55 (25%) primary tumours. Trk-C was expressed in significantly more lower stage tumours (stage 1, 2, 4S) than higher stage tumours (stage 3, 4, P < 0.04). The expression of trk-C was correlated positively with survival and negatively correlated with MYCN amplification. We also studied the function of trk-C in transfected cell lines and found that NT-3 promotes both cell survival and differentiation. Our results suggest that trk-C is involved in the biology of favourable neuroblastomas.","is_dataset_classified":null,"base_score":4.430816798843313,"endowment":4.430816798843313,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9516852","pmcid":null,"openalex_id":"https://openalex.org/W2054436155","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA 09615","title":null}],"total_grants":1,"fwci":0.832,"citation_percentile":0.74188665,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":4},{"year":2014,"count":3},{"year":2015,"count":1},{"year":2016,"count":6},{"year":2017,"count":3},{"year":2018,"count":3},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":27},{"year":2022,"count":1},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/s0959-8049(97)00309-2","host_type":"journal"},{"url":"https://doi.org/10.1016/s0959-8049(97)00309-2","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0959804997003092?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0959804997003092?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9516852","host_type":"repository"}],"fields_of_study":["Neuroblastoma Research and Treatments","Signaling Pathways in Disease","Nerve injury and regeneration","Blotting, Northern","Gene Amplification","Genes, myc","Humans","Neoplasm Proteins","Neoplasm Staging","Nerve Growth Factors","Neuroblastoma","Neurotrophin 3","Polymerase Chain Reaction","Receptor Protein-Tyrosine Kinases","Receptor, trkC","Receptors, Nerve Growth Factor","Survival Analysis","Tumor Cells, Cultured"],"mesh_terms":["Gene Amplification","Humans","Neoplasm Proteins","Neoplasm Staging","Nerve Growth Factors","Neuroblastoma","Tumor Cells, Cultured","Blotting, Northern","Survival Analysis","Polymerase Chain Reaction","Genes, myc","Receptors, Nerve Growth Factor","Receptor Protein-Tyrosine Kinases","Receptor, trkC","Neurotrophin 3"],"keywords":["Trk receptor","Neuroblastoma","Neurotrophin","Biology","Cell culture","Cancer research","Receptor","Molecular biology","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T12:58:48.584666Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}