{"doi":"10.1016/s0140-6736(86)91782-4","title":"AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO","abstract":"There are two genes related to the viral erbB gene in the human genome. c-erbB-1 is the same as the gene for the epithelial-growth-factor (EGF) receptor, and c-erbB-2 encodes a receptor-like protein very similar to, but distinct from, the EGF receptor. Hybridisation analysis of DNA from 101 fresh human malignant tumours showed that the c-erbB-2 gene was amplified in 5 of 63 adenocarcinomas and none of 38 other types of tumours, whereas the c-erbB-1/EGF-receptor gene was amplified only in 1 of 8 squamous-cell carcinomas. Thus, the protein products of the amplified c-erbB-2 gene may have a role in the evolution of adenocarcinomas, as does the EGF receptor in some squamous-cell carcinomas.","journal":"The Lancet","year":1986,"id":3140,"datarank":0.8975904421030787,"base_score":5.983936280687191,"endowment":5.983936280687191,"self_citation_contribution":0.8975904421030787,"citation_network_contribution":0.0,"self_endowment_contribution":0.8975904421030787,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":396,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0657,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"1986-04-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":34384,"name":"Kumao Toyoshima","orcid":null,"position":1,"is_corresponding":false},{"id":34385,"name":"Takashi Sugimura","orcid":null,"position":2,"is_corresponding":false},{"id":34386,"name":"Tadashi Yamamoto","orcid":"0000-0002-5938-9378","position":3,"is_corresponding":false},{"id":34387,"name":"Masaaki Terada","orcid":null,"position":4,"is_corresponding":false},{"id":34388,"name":"Hector Battifora","orcid":null,"position":5,"is_corresponding":false},{"id":34389,"name":"MartinJ. Cline","orcid":null,"position":6,"is_corresponding":false},{"id":34390,"name":"Takashi Sügimura","orcid":null,"position":7,"is_corresponding":false},{"id":34383,"name":"Jun Yokota","orcid":"0000-0002-7886-4031","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}