{"doi":"10.1016/s0140-6736(22)01052-2","title":"Interstitial lung diseases","abstract":null,"journal":"The Lancet","year":2022,"id":46988,"datarank":9.129873852803755,"base_score":6.261491684321042,"endowment":6.261491684321042,"self_citation_contribution":0.9392237526481564,"citation_network_contribution":8.190650100155597,"self_endowment_contribution":0.9392237526481564,"citer_contribution":8.190650100155597,"corpus_percentile":null,"corpus_rank":null,"citation_count":523,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":195905,"name":"Atsushi Suzuki","orcid":null,"position":1,"is_corresponding":false},{"id":217128,"name":"Toby M Maher","orcid":null,"position":2,"is_corresponding":false},{"id":217127,"name":"Marlies Wijsenbeek","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Interstitial lung diseases","abstract":"Over 200 interstitial lung diseases, from ultra rare to relatively common, are recognised. Most interstitial lung diseases are characterised by inflammation or fibrosis within the interstitial space, the primary consequence of which is impaired gas exchange, resulting in breathlessness, diminished exercise tolerance, and decreased quality of life. Outcomes vary considerably for each of the different interstitial lung diseases. In some conditions, spontaneous reversibility or stabilisation can occur, but unfortunately in many people with interstitial lung disease, especially in those manifesting progressive pulmonary fibrosis, respiratory failure and death are a sad reality. Over the past 3 years, the field of interstitial lung disease has had important advances, with the approval of drugs to treat systemic sclerosis-associated interstitial lung disease, interstitial lung disease-associated pulmonary hypertension, and different forms of progressive pulmonary fibrosis. This Seminar provides an update on epidemiology, pathogenesis, presentation, diagnosis, disease course, and management of the interstitial lung diseases that are most frequently encountered in clinical practice. Furthermore, we describe how developments have led to a shift in the classification and treatment of interstitial lung diseases that exhibit progressive pulmonary fibrosis and summarise the latest practice-changing guidelines. We conclude with an outline of controversies, uncertainties, and future directions.","is_dataset_classified":null,"base_score":6.261491684321042,"endowment":6.261491684321042,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35964592","pmcid":null,"openalex_id":"https://openalex.org/W4291010494","authors":[],"funders":[],"total_grants":0,"fwci":63.0037,"citation_percentile":0.99948219,"influential_citations":2,"citation_trend":[{"year":2017,"count":1},{"year":2022,"count":8},{"year":2023,"count":83},{"year":2024,"count":156},{"year":2025,"count":175},{"year":2026,"count":99}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0140673622010522?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0140673622010522?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/s0140-6736(22)01052-2","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35964592","host_type":"repository"},{"url":"https://pure.eur.nl/en/publications/0aaf09bd-d305-4b41-961a-1aa03844614c","host_type":"repository"}],"fields_of_study":["Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","Systemic Sclerosis and Related Diseases","Medical Imaging and Pathology Studies","Medicine","Environmental Science","Dyspnea","Exercise Tolerance","Humans","Lung","Lung Diseases, Interstitial","Pulmonary Fibrosis","Quality of Life"],"mesh_terms":["Dyspnea","Humans","Lung","Pulmonary Fibrosis","Quality of Life","Exercise Tolerance","Lung Diseases, Interstitial"],"keywords":["Interstitial lung disease","Medicine","Lung","Idiopathic pulmonary fibrosis","Pulmonary fibrosis","Interstitial space","Disease","Pathology","Intensive care medicine","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-15T03:18:45.835575Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}