{"doi":"10.1016/s0092-8674(00)82001-2","title":"The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases","abstract":"p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the cellular p300/CBP associated factor (PCAF), possesses intrinsic histone acetyltransferase activity. Here, we demonstrate that p300/CBP is not only a transcriptional adaptor but also a histone acetyltransferase. p300/CBP represents a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyltransferases. p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF.","journal":"Cell","year":1996,"id":7652,"datarank":16.049227809813573,"base_score":7.988542982737695,"endowment":7.988542982737695,"self_citation_contribution":1.1982814474106545,"citation_network_contribution":14.850946362402919,"self_endowment_contribution":1.1982814474106545,"citer_contribution":14.850946362402919,"corpus_percentile":85.6,"corpus_rank":2499,"citation_count":2946,"citer_count":188,"citers_with_citation_signal":188,"citers_with_endowment":188,"datacite_reuse_total":0,"is_dataset":false,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"1996-11-01","authors":[{"id":68909,"name":"R.Louis Schiltz","orcid":null,"position":1,"is_corresponding":false},{"id":59399,"name":"Valya R. Russanova","orcid":null,"position":2,"is_corresponding":false},{"id":49607,"name":"Bruce H. Howard","orcid":"0000-0001-9988-9724","position":3,"is_corresponding":false},{"id":59402,"name":"Yoshihiro Nakatani","orcid":null,"position":4,"is_corresponding":false},{"id":68910,"name":"Vasily Ogryzko","orcid":"0000-0002-8548-1389","position":5,"is_corresponding":false},{"id":68911,"name":"R. Louis Schiltz","orcid":"0000-0002-7314-3753","position":6,"is_corresponding":false},{"id":68908,"name":"Vasily V Ogryzko","orcid":null,"position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}