{"doi":"10.1016/s0092-8674(00)81758-4","title":"The Dermatomyositis-Specific Autoantigen Mi2 Is a Component of a Complex Containing Histone Deacetylase and Nucleosome Remodeling Activities","abstract":"Histone acetylation and deacetylation were found to be catalyzed by structurally distinct, multisubunit complexes that mediate, respectively, activation and repression of transcription. ATP-dependent nucleosome remodeling, mediated by different multisubunit complexes, was thought to be involved only in transcription activation. Here we report the isolation of a protein complex that contains both histone deacetylation and ATP-dependent nucleosome remodeling activities. The complex contains the histone deacetylases HDAC1/2, histone-binding proteins, the dermatomyositis-specific autoantigen Mi2beta, a polypeptide related to the metastasis-associated protein 1, and a novel polypeptide of 32 kDa. Patients with dermatomyositis have a high rate of malignancy. The finding that Mi2beta exists in a complex containing histone deacetylase and nucleosome remodeling activities suggests a role for chromatin reorganization in cancer metastasis.","journal":"Cell","year":1998,"id":4753,"datarank":1.006029350490412,"base_score":6.706862336602747,"endowment":6.706862336602747,"self_citation_contribution":1.006029350490412,"citation_network_contribution":0.0,"self_endowment_contribution":1.006029350490412,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":817,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0482,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"1998-10-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":49844,"name":"Gary LeRoy","orcid":"0000-0002-0769-4944","position":1,"is_corresponding":false},{"id":49845,"name":"Hans-Peter Seelig","orcid":null,"position":2,"is_corresponding":false},{"id":49846,"name":"William S. Lane","orcid":null,"position":3,"is_corresponding":false},{"id":38290,"name":"Danny Reinberg","orcid":"0000-0003-4288-2016","position":4,"is_corresponding":false},{"id":1647,"name":"Yi Zhang","orcid":"0000-0002-2789-0811","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}