{"doi":"10.1016/s0014-5793(98)00269-5","title":"Polypyrimidine tract‐binding protein interacts with HnRNP L","abstract":"<jats:p>Polypyrimidine tract‐binding protein (PTB) is involved in pre‐mRNA splicing and internal ribosomal entry site (IRES)‐dependent translation. In order to identify cellular protein(s) interacting with PTB, we performed a yeast two‐hybrid screening. Heterogeneous nuclear ribonucleoprotein L (hnRNP L) was identified as a PTB‐binding protein. The interaction between PTB and hnRNP L was confirmed in an in vitro binding assay. Both PTB and hnRNP L were found to localize in the nucleoplasm, excepting the nucleoli, in HeLa cells by the green fluorescent protein (GFP)‐fused protein detection method. The N‐terminal half of PTB (aa 1–329) and most of hnRNP L (aa 141–558) is required for the interaction between PTB and hnRNP L.</jats:p>","journal":"FEBS Letters","year":1998,"id":25155,"datarank":3.7820070560868837,"base_score":4.3694478524670215,"endowment":4.3694478524670215,"self_citation_contribution":0.6554171778700533,"citation_network_contribution":3.1265898782168304,"self_endowment_contribution":0.6554171778700533,"citer_contribution":3.1265898782168304,"corpus_percentile":null,"corpus_rank":null,"citation_count":78,"citer_count":68,"citers_with_citation_signal":61,"citers_with_endowment":61,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":148751,"name":"Ook H 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Hahm","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.3694478524670215,"endowment":4.3694478524670215,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9563502","pmcid":null,"openalex_id":"https://openalex.org/W2079101651","authors":[],"funders":[],"total_grants":0,"fwci":1.6882,"citation_percentile":0.84565717,"influential_citations":2,"citation_trend":[{"year":2013,"count":5},{"year":2014,"count":1},{"year":2015,"count":4},{"year":2018,"count":1},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":5},{"year":2023,"count":4},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2898%2900269-5","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(98)00269-5","host_type":"publisher"},{"url":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2898%2900269-5","host_type":"publisher"},{"url":"https://doi.org/10.1016/s0014-5793(98)00269-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9563502","host_type":"repository"},{"url":"https://oasis.postech.ac.kr/handle/2014.oak/20817","host_type":"repository"}],"fields_of_study":["RNA Research and Splicing","Viral Infections and Immunology Research","RNA and protein synthesis mechanisms","Medicine","Biology","DNA-Binding Proteins","Genes, Reporter","Green Fluorescent Proteins","HeLa Cells","Heterogeneous-Nuclear Ribonucleoprotein L","Heterogeneous-Nuclear Ribonucleoproteins","Humans","Luminescent Proteins","Microscopy, Fluorescence","Nuclear Proteins","Polypyrimidine Tract-Binding Protein","Protein Biosynthesis","RNA Precursors","RNA Splicing","RNA-Binding Proteins","Recombinant Fusion Proteins","Ribonucleoproteins","Sequence Deletion","beta-Galactosidase"],"mesh_terms":["beta-Galactosidase","DNA-Binding Proteins","HeLa Cells","Humans","Luminescent Proteins","Microscopy, Fluorescence","Nuclear Proteins","Recombinant Fusion Proteins","Ribonucleoproteins","RNA Precursors","RNA Splicing","Protein Biosynthesis","RNA-Binding Proteins","Sequence Deletion","Genes, Reporter","Heterogeneous-Nuclear Ribonucleoproteins","Heterogeneous-Nuclear Ribonucleoprotein L","Polypyrimidine Tract-Binding Protein","Green Fluorescent Proteins","Hela Cells"],"keywords":["Polypyrimidine tract-binding protein","Nucleoplasm","Internal ribosome entry site","Heterogeneous ribonucleoprotein particle","Ribonucleoprotein","Nucleolus","Heterogeneous nuclear ribonucleoprotein","Molecular biology","RNA splicing","Poly(A)-binding protein","Polypyrimidine tract","Binding protein","RNA-binding protein","Ribosomal protein","Translation (biology)","Chemistry","Ribosome","Biology","Cell biology","Messenger RNA","RNA","Biochemistry","Gene","Nucleus"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T00:13:29.314434Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}