{"doi":"10.1016/s0014-5793(00)01530-1","title":"Molecular chaperone properties of serum amyloid P component","abstract":"<jats:p>The selective binding of serum amyloid P component (SAP) to proteins in the pathological amyloid cross‐β fold suggests a possible chaperone role. Here we show that human SAP enhances the refolding yield of denatured lactate dehydrogenase and protects against enzyme inactivation during agitation of dilute solutions. These effects are independent of calcium ions and are not inhibited by compounds that block the amyloid recognition site on the B face of SAP, implicating the A face and/or the edges of the SAP pentamer. We discuss the possibility that the chaperone property of SAP, or its failure, may contribute to the pathogenesis of amyloidosis.</jats:p>","journal":"FEBS Letters","year":2000,"id":36436,"datarank":2.396454592733977,"base_score":4.04305126783455,"endowment":4.04305126783455,"self_citation_contribution":0.6064576901751826,"citation_network_contribution":1.789996902558794,"self_endowment_contribution":0.6064576901751826,"citer_contribution":1.789996902558794,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":51,"citers_with_citation_signal":45,"citers_with_endowment":45,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":184489,"name":"Alan Purvis","orcid":null,"position":1,"is_corresponding":false},{"id":184490,"name":"Douglas Baker","orcid":null,"position":2,"is_corresponding":false},{"id":184491,"name":"Mark B. Pepys","orcid":null,"position":3,"is_corresponding":false},{"id":184492,"name":"Steve P. Wood","orcid":null,"position":4,"is_corresponding":false},{"id":184488,"name":"Alun R. Coker","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.04305126783455,"endowment":4.04305126783455,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10812074","pmcid":null,"openalex_id":"https://openalex.org/W2096648584","authors":[],"funders":[{"funder_name":"UK Research and Innovation","grant_id":"G7900510","title":"Pentraxins and amyloidosis: from molecular mechanisms to medicines"}],"total_grants":1,"fwci":0.4907,"citation_percentile":0.64127089,"influential_citations":2,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":2},{"year":2014,"count":3},{"year":2015,"count":2},{"year":2016,"count":3},{"year":2017,"count":4},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2800%2901530-1","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2800%2901530-1","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2800%2901530-1","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2800%2901530-1","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(00)01530-1","host_type":"publisher"},{"url":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2800%2901530-1","host_type":"publisher"},{"url":"https://doi.org/10.1016/s0014-5793(00)01530-1","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10812074","host_type":"repository"},{"url":"http://discovery.ucl.ac.uk/116991/","host_type":"repository"},{"url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2800%2901530-1","host_type":""},{"url":"http://dx.doi.org/10.1016/S0014-5793(00)01530-1","host_type":""},{"url":"https://dx.doi.org/10.1016/s0014-5793(00)01530-1","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/S0014-5793(00)01530-1","host_type":""}],"fields_of_study":["Heat shock proteins research","Protein Structure and Dynamics","Enzyme Structure and Function","Chemistry","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Binding Sites","Binding, Competitive","C-Reactive Protein","Calcium","Deoxyadenine Nucleotides","Enzyme Reactivators","Enzyme Stability","Humans","L-Lactate Dehydrogenase","Methylgalactosides","Molecular Chaperones","Protein Denaturation","Protein Folding","Serum Amyloid P-Component"],"mesh_terms":["Serum Amyloid P-Component","Binding Sites","Binding, Competitive","C-Reactive Protein","Calcium","Deoxyadenine Nucleotides","Enzyme Reactivators","Enzyme Stability","Humans","L-Lactate Dehydrogenase","Methylgalactosides","Protein Denaturation","Protein Folding","Molecular Chaperones"],"keywords":["Pentamer","Serum amyloid P component","Chaperone (clinical)","Chemistry","Amyloidosis","Biochemistry","Amyloid (mycology)","Lactate dehydrogenase","Peptide","Amyloid disease","Enzyme","Biophysics","Amyloid fibril","Amyloid β","Biology","Inflammation","Internal medicine","Medicine","Immunology","Protein Denaturation","Protein Folding","Binding Sites","L-Lactate Dehydrogenase","Biomedical Sciences","Chaperone","Methylgalactosides","Binding, Competitive","Serum Amyloid P-Component","C-Reactive Protein","Deoxyadenine Nucleotides","Enzyme Reactivators","Enzyme Stability","/dk/atira/pure/core/subjects/biomedicalsciences","Humans","Calcium","Molecular Chaperones"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-10T15:58:07.964861Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}