{"doi":"10.1016/s0014-2999(98)00575-5","title":"Nitric oxide modulates eosinophil infiltration in antigen-induced airway inflammation in rats","abstract":null,"journal":"European Journal of Pharmacology","year":1998,"id":670888,"datarank":2.4754130777707957,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"self_citation_contribution":0.6238324625039509,"citation_network_contribution":1.8515806152668448,"self_endowment_contribution":0.6238324625039509,"citer_contribution":1.8515806152668448,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":48,"citers_with_citation_signal":37,"citers_with_endowment":37,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":432737,"name":"Estela Bevilacqua","orcid":"0000-0003-4178-4625","position":1,"is_corresponding":false},{"id":1752576,"name":"Sonia M Gagioti","orcid":null,"position":2,"is_corresponding":false},{"id":1752577,"name":"Iara M.S De Luca","orcid":null,"position":3,"is_corresponding":false},{"id":1752578,"name":"Renata C.O Zanardo","orcid":null,"position":4,"is_corresponding":false},{"id":1752579,"name":"Cleber E Teixeira","orcid":null,"position":5,"is_corresponding":false},{"id":1752580,"name":"Paulina Sannomiya","orcid":null,"position":6,"is_corresponding":false},{"id":453324,"name":"Edson Antunes","orcid":"0000-0003-2201-8247","position":7,"is_corresponding":false},{"id":1752581,"name":"Gilberto De Nucci","orcid":null,"position":8,"is_corresponding":false},{"id":1752575,"name":"Heloisa H.A Ferreira","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nitric oxide modulates eosinophil infiltration in antigen-induced airway inflammation in rats","abstract":"The influence of nitric oxide (NO) on eosinophil infiltration into the airways was investigated in rats actively sensitized with ovalbumin. The animals were treated chronically with the NO synthase inhibitor, N omega-Nitro-L-arginine methyl ester (L-NAME; 75 mumol rat-1 day-1), for 4 weeks. Bronchoalveolar lavage was performed at 6, 24, 48 and 72 h after intratracheal injection of ovalbumin. Intratracheal challenge of the sensitized rats with ovalbumin caused a significant increase in total leucocyte infiltration in bronchoalveolar lavage fluid both 24 and 48 h post-ovalbumin injection. Neutrophils and eosinophils peaked, respectively, at 24 h (29%) and 48 h (30%) in bronchoalveolar lavage fluid whereas the mononuclear cell did not differ significantly from the counts in non-sensitized rats at any time. At both 6 and 24 h post-ovalbumin injection, the chronic treatment of the animals with L-NAME affected neither the total nor the differential leucocyte content. However, at 48 h post-ovalbumin challenge, the total cell count was reduced by approximately 48% in the L-NAME-treated animals and this was associated with a marked inhibition (81%) of the eosinophil influx. Histological examination of the lungs from these animals (48 h post-ovalbumin challenge) also showed a prominent reduction (69.5%; P < 0.05) of the eosinophil infiltration in the respiratory segments. Our results demonstrate that NO plays a pivotal role in the eosinophil infiltration in airways of actively sensitized rats.","is_dataset_classified":null,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9822892","pmcid":null,"openalex_id":"https://openalex.org/W1984519427","authors":[],"funders":[],"total_grants":0,"fwci":2.5402,"citation_percentile":0.89469973,"influential_citations":2,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2019,"count":1},{"year":2020,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014299998005755?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014299998005755?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/s0014-2999(98)00575-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9822892","host_type":"repository"}],"fields_of_study":["Asthma and respiratory diseases","Nitric Oxide and Endothelin Effects","Neuroscience of respiration and sleep","Medicine","Biology","Animals","Asthma","Bronchoalveolar Lavage Fluid","Enzyme Inhibitors","Eosinophils","Histocytochemistry","Lung","Male","NG-Nitroarginine Methyl Ester","Nitric Oxide","Ovalbumin","Rats","Rats, Wistar"],"mesh_terms":["Animals","Asthma","Bronchoalveolar Lavage Fluid","Enzyme Inhibitors","Eosinophils","Histocytochemistry","Lung","Male","Nitric Oxide","Ovalbumin","Rats, Wistar","NG-Nitroarginine Methyl Ester","Rats"],"keywords":["Ovalbumin","Eosinophil","Bronchoalveolar lavage","Infiltration (HVAC)","Nitric oxide synthase","Cellular infiltration","Chemistry","Immunology","Nitric oxide","Inflammation","Medicine","Lung","Antigen","Asthma","Endocrinology","Internal medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T00:25:57.440768Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}