{"doi":"10.1016/j.zemedi.2023.01.004","title":"Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions","abstract":"The development of phase-shift droplets has broadened the scope of ultrasound-based biomedical applications. When subjected to sufficient acoustic pressures, the perfluorocarbon phase in phase-shift droplets undergoes a phase-transition to a gaseous state. This phenomenon, termed acoustic droplet vaporization (ADV), has been the subject of substantial research over the last two decades with great progress made in design of phase-shift droplets, fundamental physics of bubble nucleation and dynamics, and applications. Here, we review experimental approaches, carried out via high-speed microscopy, as well as theoretical models that have been proposed to study the fundamental physics of ADV including vapor nucleation and ADV-induced bubble dynamics. In addition, we highlight new developments of ADV in tissue regeneration, which is a relatively recently exploited application. We conclude this review with future opportunities of ADV for advanced applications such as in situ microrheology and pressure estimation.","journal":"Zeitschrift für Medizinische Physik","year":2023,"id":321584,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":366611,"name":"Oliver D. Kripfgans","orcid":"0000-0003-2905-1496","position":1,"is_corresponding":false},{"id":366619,"name":"J. Brian Fowlkes","orcid":"0000-0002-4536-3919","position":2,"is_corresponding":false},{"id":310273,"name":"Mario L. Fabiilli","orcid":"0000-0002-4752-9812","position":3,"is_corresponding":false},{"id":465311,"name":"Mitra Aliabouzar","orcid":"0000-0002-7441-3479","position":0,"is_corresponding":true}],"reference_count":146,"raw_metadata":null,"created_at":"2026-07-19T01:07:32.611759Z","pmid":"36775778","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}